Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model
المؤلفون المشاركون
Li, Haiming
Chai, Shoudong
Dai, Longsheng
Gu, Chengxiong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
The aim of this study was to test the effects of collagen external scaffold (CES) in intimal hyperplasia of vein grafts and explore its underlying mechanisms.
Methods.
Thirty-six New Zealand white rabbits were randomized into no-graft group, graft group, and CES group.
The rabbit arteriovenous graft model was established.
In CES group, the vein graft was wrapped around with CES.
The hemodynamic parameters of vein grafts were measured intraoperatively and 4 weeks after operation by ultrasonic examination.
Histological characteristics of vein grafts were also evaluated 4 weeks later.
The mRNA and protein levels of proliferating cell nuclear antigen (PCNA), active cleaved-caspase-3 (ClvCasp-3), and smooth muscle 22 alpha (SM22α) were measured 4 weeks later by quantitative real-time PCR and western blot.
Results.
CES significantly improved the hemodynamic stability of vein grafts, with higher blood velocity and blood flow.
Similarly, CES also markedly mitigated intimal hyperplasia and inhibited dilatation of vein grafts.
In CES group, the upexpression of PCNA and ClvCasp-3 and the downexpression of SM22α were inhibited.
Conclusion.
CES exerts beneficial effects in mitigating intimal hyperplasia and improving remodeling of autogenous vein grafts, which may be associated with reducing the proliferation and apoptosis and preserving the phenotype of VSMCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Haiming& Chai, Shoudong& Dai, Longsheng& Gu, Chengxiong. 2017. Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Haiming…[et al.]. Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Haiming& Chai, Shoudong& Dai, Longsheng& Gu, Chengxiong. Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر