Extracorporeal Hemadsorption versus Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial
المؤلفون المشاركون
Podbregar, Matej
Ihan, Alojz
Taleska Stupica, Gordana
Sostaric, Maja
Bozhinovska, Marija
Rupert, Lea
Bosnic, Zoran
Jerin, Ales
Klokocovnik, Tomislav
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-30
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Extracorporeal hemadsorption may reduce inflammatory reaction in cardiopulmonary bypass (CPB) surgery.
Glucocorticoids have been used during open-heart surgery for alleviation of systemic inflammation after CPB.
We compared intraoperative hemadsorption and methylprednisolone, with usual care, during complex cardiac surgery on CPB, for inflammatory responses, hemodynamics, and perioperative course.
Seventy-six patients with prolonged CPB were recruited and randomized, with 60 included in final analysis.
Allocation was into three groups: Methylprednisolone (n = 20), Cytosorb (n = 20), and Control group (usual care, n = 20).
Proinflammatory (TNF-α, IL-1β, IL-6, and IL-8) and anti-inflammatory (IL-10) cytokines which complement C5a, CD64, and CD163 expression by immune cells were analyzed within the first five postoperative days, in addition to hemodynamic and clinical outcome parameters.
Methylprednisolone group, compared to Cytosorb and Control had significantly lower levels of TNF-α (until the end of surgery, p<0.001), IL-6 (until 48 h after surgery, p<0.001), and IL-8 (until 24 h after surgery, p<0.016).
CD64 expression on monocytes was the highest in the Cytosorb group and lasted until the 5th postoperative day (p<0.016).
IL-10 concentration (until the end of surgery) and CD163 expression on monocytes (until 48 h after surgery) were the highest in the Methylprednisolone group (p<0.016, for all measurements between three groups).
No differences between groups in the cardiac index or clinical outcome parameters were found.
Methylprednisolone more effectively ameliorates inflammatory responses after CPB surgery compared to hemadsorption and usual care.
Hemadsorption compared with usual care causes higher prolonged expression of CD64 on monocytes but short lasting expression of CD163 on granulocytes.
Hemadsorption with CytoSorb® was safe and well tolerated.
This trial is registered with clinicaltrials.gov (NCT02666703).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taleska Stupica, Gordana& Sostaric, Maja& Bozhinovska, Marija& Rupert, Lea& Bosnic, Zoran& Jerin, Ales…[et al.]. 2020. Extracorporeal Hemadsorption versus Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1138630
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taleska Stupica, Gordana…[et al.]. Extracorporeal Hemadsorption versus Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial. Cardiovascular Therapeutics No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1138630
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taleska Stupica, Gordana& Sostaric, Maja& Bozhinovska, Marija& Rupert, Lea& Bosnic, Zoran& Jerin, Ales…[et al.]. Extracorporeal Hemadsorption versus Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1138630
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138630
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر