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Identification of Genetic Biomarkers for Diagnosis of Myocardial Infarction Compared with Angina Patients
المؤلفون المشاركون
Zhang, Yuanyuan
Tian, Chunyang
Liu, Xuejian
Zhang, He
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Myocardial infarction (MI) is the most terrible appearance of cardiovascular disease.
The incidence of heart failure, one of the complications of MI, has increased in the past few decades.
Therefore, the identification of MI from angina patients and the determination of new diagnoses and therapies of MI are increasingly important.
The present study was aimed at identifying differentially expressed genes and miRNAs as biomarkers for the clinical and prognosis factors of MI compared with angina using microarray data analysis.
Methods.
Differentially expressed miRNAs and genes were manifested by GEO2R.
The biological function of differentially expressed genes (DEGs) was examined by GO and KEGG.
The construction of a protein-protein network was explored by STRING.
cytoHubba was utilized to screen hub genes.
Analysis of miRNA-gene pairs was executed by the miRWalk 3.0 database.
The miRNA-target pairs overlapped with hub genes were seen as key genes.
Logistic regressive analysis was performed by SPSS.
Results.
A number of 779 DEGs were recorded.
The biological function containing extracellular components, signaling pathways, and cell adhesion was enriched.
Twenty-four hub genes and three differentially expressed miRNAs were noted.
Eight key genes were demonstrated, and 6 out of these 8 key genes were significantly related to clinical and prognosis factors following MI.
Conclusions.
CALCA, CDK6, MDM2, NRXN1, SOCS3, VEGFA, SMAD4, NCAM1, and hsa-miR-127-5p were thought to be potential diagnosis biomarkers for MI.
Meanwhile, CALCA, CDK6, NRXN1, SMAD4, SOCS3, and NCAM1 were further identified to be potential diagnosis and therapy targets for MI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yuanyuan& Tian, Chunyang& Liu, Xuejian& Zhang, He. 2020. Identification of Genetic Biomarkers for Diagnosis of Myocardial Infarction Compared with Angina Patients. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1138634
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yuanyuan…[et al.]. Identification of Genetic Biomarkers for Diagnosis of Myocardial Infarction Compared with Angina Patients. Cardiovascular Therapeutics No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1138634
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yuanyuan& Tian, Chunyang& Liu, Xuejian& Zhang, He. Identification of Genetic Biomarkers for Diagnosis of Myocardial Infarction Compared with Angina Patients. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1138634
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138634
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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