Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Castration-Resistant Prostate Cancer Patients Who Received Cabazitaxel Chemotherapy
المؤلفون المشاركون
Makiyama, Kazuhide
Yokomizo, Yumiko
Teranishi, Jun-ichi
Yao, Masahiro
Uemura, Hiroji
Yumura, Yasushi
Tatenuma, Tomoyuki
Kishida, Takeshi
Miyoshi, Yasuhide
Kobayashi, Kazuki
Uemura, Koichi
Yamashita, Daisuke
Jikuya, Ryosuke
Abe, Koichi
Izumi, Koji
Udagawa, Koichi
Kawahara, Takashi
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction and Objectives.
An elevated neutrophil-to-lymphocyte ratio (NLR) has been suggested to be associated with a poor prognosis in several cancers.
We evaluated the utility of an elevated NLR as a biomarker to predict the prognosis of metastatic castration-resistant prostate cancer (mCRPC) patients treated with cabazitaxel (CBZ).
Methods.
We analyzed 47 patients who received CBZ chemotherapy for mCRPC in our institutions.
The NLR was calculated using the neutrophil and lymphocyte counts before CBZ chemotherapy.
We determined the NLR cut-off value based on the sensitivity and specificity levels derived from area under the receiver operator characteristic curves for death.
A multivariate analysis was performed to investigate the association between the NLR and the prognosis.
Results.
The median overall survival (OS) after CBZ was 10.0 months (range: 6.3–13.2).
The median OS was shorter in patients with a high NLR (≥3.83) than in those with a low NLR (<3.83) (5.8 versus 13.2 months, p=0.018).
In the multivariate analysis, the NLR, patient age, and lymph node (LN) metastasis were independent predictors of the OS (hazard ratio 3.01, p=0.030; hazard ratio 3.10, p=0.029; hazard ratio 12.38, p=0.001, resp.).
Conclusions.
NLR might be a useful prognostic biomarker in mCRPC patients treated with CBZ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uemura, Koichi& Kawahara, Takashi& Yamashita, Daisuke& Jikuya, Ryosuke& Abe, Koichi& Tatenuma, Tomoyuki…[et al.]. 2017. Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Castration-Resistant Prostate Cancer Patients Who Received Cabazitaxel Chemotherapy. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uemura, Koichi…[et al.]. Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Castration-Resistant Prostate Cancer Patients Who Received Cabazitaxel Chemotherapy. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1138662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uemura, Koichi& Kawahara, Takashi& Yamashita, Daisuke& Jikuya, Ryosuke& Abe, Koichi& Tatenuma, Tomoyuki…[et al.]. Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Castration-Resistant Prostate Cancer Patients Who Received Cabazitaxel Chemotherapy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر