Serum Levels of Matrix Metalloproteinase-1 in Brazilian Patients with Benign Prostatic Hyperplasia or Prostate Cancer
المؤلفون المشاركون
Nóbrega, Otávio Toledo
Sousa, Vinícius Carolino
Franco Moraes, Clayton
El-Chaer, William Khalil
Tonet-Furioso, Audrey Cecília
Morais Junior, Gilberto Santos
Avelar, Gleiciane Gontijo
Henriques, Adriane Dallanora
المصدر
Current Gerontology and Geriatrics Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Metalloproteinases (MMPs) are involved in metastatic tumor processes, with changes in circulating levels detected in several cancer types.
Here, we compare serum concentrations of metalloproteinase-1 (MMP-1) across individuals clinically diagnosed with prostate cancer (PCa) or benign prostatic hyperplasia (BPH), correcting results for the rs495366 single nucleotide polymorphism (SNP) that predisposes to differential MMP-1 levels.
196 men aged ≥50 years were followed at a university hospital urology outpatient clinic, with clinical, anthropometric, and rectal examinations performed by one urologist.
Blood samples obtained prior to any clinical intervention provided baseline MMP-1 and total/free PSA levels as well as metabolic, hormonal, and inflammatory markers.
The SNP was genotyped by real-time PCR.
Participants with medical and/or laboratory profile compatible with malignancy composed the PCa group when confirmed by the Gleason scale.
As expected, A-allele homozygotes showed reduced levels of MMP-1.
Genotype-adjusted analyses revealed the mean MMP-1 level as 2-fold higher in PCa carriers compared to BPH patients.
No other differences were found according to the prostatic condition or genotypic distribution, except for the expected raise in total and free PSA levels in PCa.
In conclusion, increased serum levels of MMP-1 were observed in this context of prostatic malignancy compared to a benign phenotype, regardless of a genetic influence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Chaer, William Khalil& Tonet-Furioso, Audrey Cecília& Morais Junior, Gilberto Santos& Sousa, Vinícius Carolino& Avelar, Gleiciane Gontijo& Henriques, Adriane Dallanora…[et al.]. 2020. Serum Levels of Matrix Metalloproteinase-1 in Brazilian Patients with Benign Prostatic Hyperplasia or Prostate Cancer. Current Gerontology and Geriatrics Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138666
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Chaer, William Khalil…[et al.]. Serum Levels of Matrix Metalloproteinase-1 in Brazilian Patients with Benign Prostatic Hyperplasia or Prostate Cancer. Current Gerontology and Geriatrics Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1138666
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Chaer, William Khalil& Tonet-Furioso, Audrey Cecília& Morais Junior, Gilberto Santos& Sousa, Vinícius Carolino& Avelar, Gleiciane Gontijo& Henriques, Adriane Dallanora…[et al.]. Serum Levels of Matrix Metalloproteinase-1 in Brazilian Patients with Benign Prostatic Hyperplasia or Prostate Cancer. Current Gerontology and Geriatrics Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138666
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138666
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر