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Purification, Characterization, and Mode of Action of Pentocin JL-1, a Novel Bacteriocin Isolated from Lactobacillus pentosus, against Drug-Resistant Staphylococcus aureus
المؤلفون المشاركون
Jiang, Han
Zou, Jiong
Cheng, Hui
Fang, Jiehong
Huang, Guangrong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Staphylococcus aureus and its drug-resistant strains, which threaten public health and food safety, are in need of effective control by biopreservatives.
A novel bacteriocin, pentocin JL-1, produced by Lactobacillus pentosus that was isolated from the intestinal tract of Chiloscyllium punctatum, was purified by a four-step chromatographic process.
Mass spectrometry based on MALDI-TOF indicated that pentocin JL-1 has a molecular mass of 2987.23 Da.
Only six of the twenty-five amino acids could be identified by Edman degradation.
This bacteriocin is thermostable and tolerates a pH range of 5–7.
Also, it is sensitive to proteinase K, trypsin, pepsin, and alkaline protease.
This bacteriocin has a broad inhibitory spectrum against both Gram-positive and Gram-negative strains and in particular is effective against multidrug-resistant S.
aureus.
Additionally, we showed that the cell membrane is the target of pentocin JL-1 against methicillin-resistant S.
aureus (MRSA), causing a loss of proton motive force.
Furthermore, pentocin JL-1 has a drastic impact on the structure and integrity of MRSA cells.
These results suggest that pentocin JL-1 has potential as a biopreservative in the food industry.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Han& Zou, Jiong& Cheng, Hui& Fang, Jiehong& Huang, Guangrong. 2017. Purification, Characterization, and Mode of Action of Pentocin JL-1, a Novel Bacteriocin Isolated from Lactobacillus pentosus, against Drug-Resistant Staphylococcus aureus. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Han…[et al.]. Purification, Characterization, and Mode of Action of Pentocin JL-1, a Novel Bacteriocin Isolated from Lactobacillus pentosus, against Drug-Resistant Staphylococcus aureus. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1138694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Han& Zou, Jiong& Cheng, Hui& Fang, Jiehong& Huang, Guangrong. Purification, Characterization, and Mode of Action of Pentocin JL-1, a Novel Bacteriocin Isolated from Lactobacillus pentosus, against Drug-Resistant Staphylococcus aureus. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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