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Sodium Fluorescein-Guided Resection under the YELLOW 560 nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience
المؤلفون المشاركون
Zhang, Ningning
Tian, Hailong
Huang, Dezhang
Meng, Xianbing
Guo, Wenqiang
Wang, Chaochao
Yin, Xin
Zhang, Hongying
Jiang, Bin
He, Zheng
Wang, Zhigang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Sodium fluorescein (FL) had been safely used in fluorescence-guided microsurgery for imaging various brain tumors.
Under the YELLOW 560 nm surgical microscope filter, low-dose FL as a fluorescent dye helps in visualization.
Our study investigated the safety and efficacy of this innovative technique in malignant glioma (MG) patients.
Patients and Method.
38 patients suffering from MGs confirmed by pathology underwent FL-guided resection under YELLOW 560 nm surgical microscope filter.
We retrospectively analyzed the clinical characters, microsurgery procedure, extent of resection, pathology of MGs, progression-free survival (PFS), and overall survival (OS).
Results.
Thirty-eight patients had MGs (10 WHO grade III, 28 WHO grade IV).
With YELLOW 560 nm surgical microscope filter combined with neuronavigation, sodium fluorescein-guided gross total resection (GTR) was achieved in 35 (92.1%) patients and subtotal resection in 3 (7.69%).
The sensitivity and specificity of FL were 94.4% and 88.6% regardless of radiographic localization.
Intraoperatively, 10 biopsies (10/28 FL[+]) showed “low” or “high” fluorescence in non-contrast-enhancement region and are also confirmed by pathology.
Our data showed 6-month PFS of 92.3% and median survival of 11 months.
Conclusion.
FL-guided resection of MGs under the YELLOW 560 nm surgical microscope filter combined with neuronavigation was safe and effective, especially in non-contrast-MRI regions.
It is feasible for improving the extent of resection in MGs especially during emergency cases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Ningning& Tian, Hailong& Huang, Dezhang& Meng, Xianbing& Guo, Wenqiang& Wang, Chaochao…[et al.]. 2017. Sodium Fluorescein-Guided Resection under the YELLOW 560 nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138756
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Ningning…[et al.]. Sodium Fluorescein-Guided Resection under the YELLOW 560 nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138756
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Ningning& Tian, Hailong& Huang, Dezhang& Meng, Xianbing& Guo, Wenqiang& Wang, Chaochao…[et al.]. Sodium Fluorescein-Guided Resection under the YELLOW 560 nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138756
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138756
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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