Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer
المؤلفون المشاركون
Riccio, Eleonora
Santangelo, Michele L.
Dodaro, Concetta
Tammaro, Vincenzo
Carlomagno, Nicola
Calogero, Armando
Peluso, Gaia
Incollingo, Paola
Minieri, Gianluca
Rupealta, Niccolò
Chiacchio, Gaetano
Sandoval Sotelo, Maria Laura
Pisani, Antonio
Bracale, Umberto Marcello
Sabbatini, Massimo
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Introduction.
Gastric cancer is the fifth most common cancer and the third cause of cancer death.
The clinical outcomes of the patients are still not encouraging with a low rate of 5 years’ survival.
Often the disease is diagnosed at advanced stages and this obviously negatively affects patients outcomes.
A deep understanding of molecular basis of gastric cancer can lead to the identification of diagnostic, predictive, prognostic, and therapeutic biomarkers.
Main Body.
This paper aims to give a global view on the molecular classification and mechanisms involved in the development of the tumour and on the biomarkers for gastric cancer.
We discuss the role of E-cadherin, HER2, fibroblast growth factor receptor (FGFR), MET, human epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (HGFR), mammalian target of rapamycin (mTOR), microsatellite instability (MSI), PD-L1, and TP53.
We have also considered in this manuscript new emerging biomarkers as matrix metalloproteases (MMPs), microRNAs, and long noncoding RNAs (lncRNAs).
Conclusions.
Identifying and validating diagnostic, prognostic, predictive, and therapeutic biomarkers will have a huge impact on patients outcomes as they will allow early detection of tumours and also guide the choice of a targeted therapy based on specific molecular features of the cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carlomagno, Nicola& Incollingo, Paola& Tammaro, Vincenzo& Peluso, Gaia& Rupealta, Niccolò& Chiacchio, Gaetano…[et al.]. 2017. Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138762
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carlomagno, Nicola…[et al.]. Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1138762
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carlomagno, Nicola& Incollingo, Paola& Tammaro, Vincenzo& Peluso, Gaia& Rupealta, Niccolò& Chiacchio, Gaetano…[et al.]. Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138762
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138762
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر