Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity
المؤلفون المشاركون
Camacho-Morales, Alberto
Fuentes-Mera, Lizeth
Maldonado-Ruiz, Roger
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Central nervous system (CNS) senses energy homeostasis by integrating both peripheral and autonomic signals and responding to them by neurotransmitters and neuropeptides release.
Although it is previously considered an immunologically privileged organ, we now know that this is not so.
Cells belonging to the immune system, such as B and T lymphocytes, can be recruited into the CNS to face damage or infection, in addition to possessing resident immunological cells, called microglia.
In this way, positive energy balance during obesity promotes an inflammatory state in the CNS.
Saturated fatty acids from the diet have been pointed out as powerful candidates to trigger immune response in peripheral system and in the CNS.
However, how central immunity communicates to peripheral immune response remains to be clarified.
Recently there has been a great interest in the neuropeptides, POMC derived peptides, ghrelin, and leptin, due to their capacity to suppress or induce inflammatory responses in the brain, respectively.
These may be potential candidates to treat different pathologies associated with autoimmunity and inflammation.
In this review, we will discuss the role of lipotoxicity associated with positive energy balance during obesity in proinflammatory response in microglia, B and T lymphocytes, and its modulation by neuropeptides.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maldonado-Ruiz, Roger& Fuentes-Mera, Lizeth& Camacho-Morales, Alberto. 2017. Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138814
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maldonado-Ruiz, Roger…[et al.]. Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138814
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maldonado-Ruiz, Roger& Fuentes-Mera, Lizeth& Camacho-Morales, Alberto. Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138814
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138814
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر