Basal and Activated Calcium Sensitization Mediated by RhoARho Kinase Pathway in Rats with Genetic and Salt Hypertension
المؤلفون المشاركون
Behuliak, Michal
Kuneš, Jaroslav
Bencze, Michal
Vaněčková, Ivana
Zicha, Josef
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Calcium sensitization mediated by RhoA/Rho kinase pathway can be evaluated either in the absence (basal calcium sensitization) or in the presence of endogenous vasoconstrictor systems (activated calcium sensitization).
Our aim was to compare basal and activated calcium sensitization in three forms of experimental hypertension with increased sympathetic tone and enhanced calcium entry—spontaneously hypertensive rats (SHR), heterozygous Ren-2 transgenic rats (TGR), and salt hypertensive Dahl rats.
Activated calcium sensitization was determined as blood pressure reduction induced by acute administration of Rho kinase inhibitor fasudil in conscious rats with intact sympathetic nervous system (SNS) and renin-angiotensin system (RAS).
Basal calcium sensitization was studied as fasudil-dependent difference in blood pressure response to calcium channel opener BAY K8644 in rats subjected to RAS and SNS blockade.
Calcium sensitization was also estimated from reduced development of isolated artery contraction by Rho kinase inhibitor Y-27632.
Activated calcium sensitization was enhanced in all three hypertensive models (due to the hyperactivity of vasoconstrictor systems).
In contrast, basal calcium sensitization was reduced in SHR and TGR relative to their controls, whereas it was augmented in salt-sensitive Dahl rats relative to their salt-resistant controls.
Similar differences in calcium sensitization were seen in femoral arteries of SHR and Dahl rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Behuliak, Michal& Bencze, Michal& Vaněčková, Ivana& Kuneš, Jaroslav& Zicha, Josef. 2017. Basal and Activated Calcium Sensitization Mediated by RhoARho Kinase Pathway in Rats with Genetic and Salt Hypertension. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Behuliak, Michal…[et al.]. Basal and Activated Calcium Sensitization Mediated by RhoARho Kinase Pathway in Rats with Genetic and Salt Hypertension. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1138861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Behuliak, Michal& Bencze, Michal& Vaněčková, Ivana& Kuneš, Jaroslav& Zicha, Josef. Basal and Activated Calcium Sensitization Mediated by RhoARho Kinase Pathway in Rats with Genetic and Salt Hypertension. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر