Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch
المؤلفون المشاركون
Liao, Donghua
Zhao, Jingbo
Gregersen, Hans
المصدر
Computational Intelligence and Neuroscience
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Intestinal sensitivity to mechanical stimuli has been studied intensively in visceral pain studies.
The ability to sense different stimuli in the gut and translate these to physiological outcomes relies on the mechanosensory and transductive capacity of intrinsic intestinal nerves.
However, the nature of the mechanosensitive channels and principal mechanical stimulus for mechanosensitive receptors are unknown.
To be able to characterize intestinal mechanoelectrical transduction, that is, the molecular basis of mechanosensation, comprehensive mathematical models to predict responses of the sensory neurons to controlled mechanical stimuli are needed.
This study aims to develop a biophysically based mathematical model of the myenteric neuron with the parameters constrained by learning from existing experimental data.
Findings.
The conductance-based single-compartment model was selected.
The parameters in the model were optimized by using a combination of hand tuning and automated estimation.
Using the optimized parameters, the model successfully predicted the electrophysiological features of the myenteric neurons with and without mechanical stimulation.
Conclusions.
The model provides a method to predict features and levels of detail of the underlying physiological system in generating myenteric neuron responses.
The model could be used as building blocks in future large-scale network simulations of intrinsic primary afferent neurons and their network.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liao, Donghua& Zhao, Jingbo& Gregersen, Hans. 2020. Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch. Computational Intelligence and Neuroscience،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138872
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liao, Donghua…[et al.]. Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch. Computational Intelligence and Neuroscience No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138872
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liao, Donghua& Zhao, Jingbo& Gregersen, Hans. Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch. Computational Intelligence and Neuroscience. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138872
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138872
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر