Favorable Outcomes of Chinese HCV-Related Cirrhotic Patients with Sustained Virological Response after Pegylated Interferon Plus Ribavirin Treatment
المؤلفون المشاركون
Gao, Zhiliang
Zhang, Geng-lin
Zhang, Ting
Zhang, Xiao-hong
Zhao, Zhixin
Lin, Chao-shuang
Chen, You-ming
Cai, Qing-xian
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Few studies have conducted follow-up investigations of the clinical course in HCV-related cirrhotic patients who achieved a sustained virological response (SVR) with pegylated interferon plus ribavirin treatment (PegIFN + RBV).
We investigated the clinical course and laboratory data in a prospective cohort study enrolling HCV-related cirrhotic patients who received PegIFN + RBV between August 2008 and July 2013 in China.
Complete blood counts, liver function tests, and HCV-RNA were serially examined.
Liver-related complications were recorded.
To detect hepatocellular carcinoma (HCC), alpha-fetoprotein assays, and ultrasound scans were repeated at 6-month intervals.
Twenty-five patients were enrolled, including 8 patients with decompensation events before treatment.
Eighteen patients achieved SVR with a mean follow-up period of 25.78 months.
During the follow-up period, only one patient exhibited HCV-RNA positivity and no decompensation events were detected, but 4 patients developed HCC after SVR.
APRI decreased more in patients with SVR than in patients with non-SVR (median, −1.33 versus 0.86, P<0.001).
The albumin levels and platelet counts significantly increased during the follow-up period after SVR (44.27±4.09 versus 42.63±4.37, P=0.037 and 173.89±87.36 versus 160.11±77.97, P=0.047).
These data indicated that HCV-related cirrhotic patients with SVR after PegIFN + RBV may have a favorable clinical course and improvements in laboratory data.
Moreover, HCC should be monitored.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Geng-lin& Chen, You-ming& Zhang, Ting& Cai, Qing-xian& Zhang, Xiao-hong& Zhao, Zhixin…[et al.]. 2017. Favorable Outcomes of Chinese HCV-Related Cirrhotic Patients with Sustained Virological Response after Pegylated Interferon Plus Ribavirin Treatment. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138889
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Geng-lin…[et al.]. Favorable Outcomes of Chinese HCV-Related Cirrhotic Patients with Sustained Virological Response after Pegylated Interferon Plus Ribavirin Treatment. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138889
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Geng-lin& Chen, You-ming& Zhang, Ting& Cai, Qing-xian& Zhang, Xiao-hong& Zhao, Zhixin…[et al.]. Favorable Outcomes of Chinese HCV-Related Cirrhotic Patients with Sustained Virological Response after Pegylated Interferon Plus Ribavirin Treatment. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138889
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138889
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر