Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration

المؤلفون المشاركون

Thorne, Peter R.
Chang, Hao
Sreebhavan, Sreevalsan
Telang, Ravindra S.
Tingle, Malcolm
Vlajkovic, Srdjan M.

المصدر

BioMed Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-01-18

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Noise-induced hearing loss (NIHL) is a global health problem affecting over 5% of the population worldwide.

We have shown previously that acute noise-induced cochlear injury can be ameliorated by administration of drugs acting on adenosine receptors in the inner ear, and a selective A1 adenosine receptor agonist adenosine amine congener (ADAC) has emerged as a potentially effective treatment for cochlear injury and resulting hearing loss.

This study investigated pharmacokinetic properties of ADAC in rat perilymph after systemic (intravenous) administration using a newly developed liquid chromatography-tandem mass spectrometry detection method.

The method was developed and validated in accordance with the USA FDA guidelines including accuracy, precision, specificity, and linearity.

Perilymph was sampled from the apical turn of the cochlea to prevent contamination with the cerebrospinal fluid.

ADAC was detected in cochlear perilymph within two minutes following intravenous administration and remained in perilymph above its minimal effective concentration for at least two hours.

The pharmacokinetic pattern of ADAC was significantly altered by exposure to noise, suggesting transient changes in permeability of the blood-labyrinth barrier and/or cochlear blood flow.

This study supports ADAC development as a potential clinical otological treatment for acute sensorineural hearing loss caused by exposure to traumatic noise.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chang, Hao& Telang, Ravindra S.& Sreebhavan, Sreevalsan& Tingle, Malcolm& Thorne, Peter R.& Vlajkovic, Srdjan M.. 2017. Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138902

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chang, Hao…[et al.]. Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138902

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chang, Hao& Telang, Ravindra S.& Sreebhavan, Sreevalsan& Tingle, Malcolm& Thorne, Peter R.& Vlajkovic, Srdjan M.. Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138902

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1138902