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Bacterial Community Profile of the Gut Microbiota Differs between Hypercholesterolemic Subjects and Controls
المؤلفون المشاركون
Saavedra, Nicolás
Salazar, Luis A.
Cuevas, Alejandro
Zambrano, Tomás
Lanas, Fernando
Rebolledo, Camilo
Acuña, Jacquelinne J.
Jorquera, Milko A.
Saavedra, Kathleen
Martínez, Claudia
Serón, Pamela
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The role of gut microbiota in the development of metabolic illnesses has been abundantly demonstrated.
Recent studies suggest that gut microbiota alterations may also be related to the development of hypercholesterolemia.
Therefore, we aimed to assess differences in the gut bacterial community profiles between hypercholesterolemic subjects and controls.
Thirty cases diagnosed with hypercholesterolemia and 27 normocholesterolemic controls were included.
A fasting whole blood sample was obtained to determine the lipid profile.
In parallel, stool samples were collected and total DNA was isolated to assess the bacterial community profiles by denaturing gradient gel electrophoresis (DGGE).
In addition, the Richness, Shannon-Weaver, and Simpson indexes were used to evaluate the richness and diversity of bacterial communities.
As expected, serum concentrations of total cholesterol, triglycerides, and LDL-cholesterol were significantly higher in the cases compared with controls.
Moreover, DGGE analysis showed a lower richness and diversity of bacterial communities in hypercholesterolemic subjects.
In conclusion, our results showed differences in the profiles of bacterial communities between hypercholesterolemic subjects and controls, suggesting a possible role of the gut microbiota in the development of hypercholesterolemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rebolledo, Camilo& Cuevas, Alejandro& Zambrano, Tomás& Acuña, Jacquelinne J.& Jorquera, Milko A.& Saavedra, Kathleen…[et al.]. 2017. Bacterial Community Profile of the Gut Microbiota Differs between Hypercholesterolemic Subjects and Controls. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rebolledo, Camilo…[et al.]. Bacterial Community Profile of the Gut Microbiota Differs between Hypercholesterolemic Subjects and Controls. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1138919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rebolledo, Camilo& Cuevas, Alejandro& Zambrano, Tomás& Acuña, Jacquelinne J.& Jorquera, Milko A.& Saavedra, Kathleen…[et al.]. Bacterial Community Profile of the Gut Microbiota Differs between Hypercholesterolemic Subjects and Controls. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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