Clinical Patterns and Outcome of Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Kim, Suk Bae
Ahn, Seon Young
Song, Il Han
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Nonalcoholic fatty liver disease (NAFLD) may develop into liver cirrhosis and hepatocellular carcinoma (HCC).
The aim of this study was to compare the clinical patterns and survival outcomes of NAFLD-related HCC patients and those of alcoholic liver disease (ALD)-related or hepatitis B virus (HBV)-related HCC patients.
Methods.
A total of 622 HCC patients with associated NAFLD (n = 56), ALD (n = 173), or HBV infection (n = 393) were enrolled.
The clinical characteristics and survival were analyzed according to the underlying liver diseases.
Results.
NAFLD-related HCC patients were more commonly older women and had more metabolic risk factors but were less likely to have cirrhosis and ascites, compared to ALD-related or HBV-related HCC patients.
NAFLD-related HCC more often had an infiltrative pattern (P=0.047), a larger tumor (P=0.001), more macrovascular invasion (P=0.022), and exceeded the Milan criteria (P=0.001), but was less frequently diagnosed during tumor surveillance (P=0.025).
Survival analysis did not show any difference among NAFLD-related, ALD-related, and HBV-related HCC patients.
Furthermore, propensity score matching analysis did not reveal a significant difference in the median survival between the different groups (NAFLD vs.
ALD, 14.0 months [95% confidence interval (CI), 2.0–26.0] vs.
13.0 months [95% CI, 0–26.3]; P=0.667, NAFLD vs.
HBV, 14.0 months [95% CI, 2.0–26.0] vs.
12.0 months [95% CI, 4.3–17.8]; P=0.573).
Conclusions.
NAFLD-related HCCs were more often detected at an advanced stage with infiltrative patterns, although they showed no significant difference in survival compared to ALD-related or HBV-related HCCs.
A future prospective research should be focused on identifying NAFLD patients who require strict surveillance in order to early detect and timely treat HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahn, Seon Young& Kim, Suk Bae& Song, Il Han. 2020. Clinical Patterns and Outcome of Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahn, Seon Young…[et al.]. Clinical Patterns and Outcome of Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1139013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahn, Seon Young& Kim, Suk Bae& Song, Il Han. Clinical Patterns and Outcome of Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر