Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Shin, Sung Ho
Shin, Mi-Rae
Roh, Seong-Soo
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Nonalcoholic fatty liver disease (NAFLD) has been a major cause of a chronic liver disease over recent decades and increasing worldwide in parallel with the remarkable growth of obesity.
In the present study, we investigate the ameliorative effects of PCM, a combination of Diospyros kaki fruit and Citrus unshiu peel mixture, on high-fat diet- (HFD-) induced NAFLD and clarify the potential mechanisms.
PCM in HFD-fed mice was orally administered at a dose of 50 or 100 mg/kg subsequently for 2 months.
Thereafter, lipid metabolism parameters and fat synthesis-related genes in the mouse liver were evaluated.
Subsequently, body weight changes, liver weight, serum liver function and lipid profiles, and liver pathology were examined, and the relative levels of fatty acid synthesis and β-oxidation gene expression were evaluated by western blot.
Serum AST, ALT, and TG levels in the HFD control mice were significantly higher than those of normal mice.
Compared with HFD control mice, PCM supplementation increased phosphorylation of AMP-activated protein kinase (AMPK).
Peroxisome proliferator-activated receptor (PPAR) α was significantly increased by PCM administration.
Continuously, the activation of PPARα significantly elevated carnitine palmitoyltransferase 1 (CPT-1), a key enzyme in fatty acid β-oxidation, and mitochondrial uncoupling protein 2 (UCP-2), thermogenic regulatory genes, in PCM-treated mice compared with those of HFD control mice.
Moreover, PCM inhibits lipogenesis and cholesterol synthesis via suppression of sterol regulatory element binding protein-1 (SREBP-1) and SREBP-2 and its target genes such as acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1), and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
Taken together, these effects were mediated through activation of AMPK.
In the conclusion, PCM improved liver damage in HFD-fed mice and attenuated NAFLD by the activation of PPARα and the inhibition of SREBPs expression via AMPK-dependent pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shin, Mi-Rae& Shin, Sung Ho& Roh, Seong-Soo. 2020. Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1139040
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shin, Mi-Rae…[et al.]. Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1139040
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shin, Mi-Rae& Shin, Sung Ho& Roh, Seong-Soo. Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1139040
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139040
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر