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Effect of Low Positive End of Treatment Viral Load with Direct-Acting Antiviral Therapy on Sustained Virologic Response
المؤلفون المشاركون
Pal, Vabhave
Ancha, Nirupama
Mann, Jena
Modi, Apurva A.
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-27
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Direct-acting antivirals (DAAs) are highly effective treatments against hepatitis C virus (HCV), with sustained virologic response (SVR) rates of 93–100% against all genotypes.
In most patients, viral load (VL) becomes undetectable four weeks into treatment, but rarely a low positive VL may be observed at the end of treatment (EOT).
This study was conducted to determine the effect of low positive EOT VLs with DAA therapies on SVR at 12 and 24 weeks.
Methods.
A retrospective chart review was conducted from January 2014 to December 2018 on 1256 HCV patients of all genotypes (1–6) who had received DAA therapy at two large hepatology referral centers.
Baseline demographic data, along with VL at week four, EOT, and SVR12/24 time points were collected for patients that had positive EOT VL.
Treatment outcome for any patient with positive EOT VL was noted.
Results.
Eight out of 1256 patients treated with varying DAA therapies were observed to have low positive EOT VLs ranging from <15 to 235 IU/mL.
One patient had a negative EOT VL, but 23 IU/mL at week four after EOT.
All eight patients who had low positive EOT VLs and one patient who had a low positive VL at four weeks after EOT achieved SVR at weeks 12 and 24.
One of the eight patients had cirrhosis.
The majority of patients were genotype 1a.
Conclusion.
In the DAA treatment era, low levels of detectable HCV RNA at EOT does not predict treatment failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pal, Vabhave& Ancha, Nirupama& Mann, Jena& Modi, Apurva A.. 2020. Effect of Low Positive End of Treatment Viral Load with Direct-Acting Antiviral Therapy on Sustained Virologic Response. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1139044
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pal, Vabhave…[et al.]. Effect of Low Positive End of Treatment Viral Load with Direct-Acting Antiviral Therapy on Sustained Virologic Response. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1139044
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pal, Vabhave& Ancha, Nirupama& Mann, Jena& Modi, Apurva A.. Effect of Low Positive End of Treatment Viral Load with Direct-Acting Antiviral Therapy on Sustained Virologic Response. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1139044
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139044
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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