Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis
المؤلفون المشاركون
Kaneko, Shuichi
Komura, Takuya
Kagaya, Takashi
Takayama, Hideo
Yanagi, Masahiro
Yoshio, Takatoshi
Sugimoto, Saiho
Nishino, Michiko
Orita, Noriaki
Asahina, Yoshiro
Nishikawa, Masashi
Unoura, Masashi
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
Cytomegalovirus (CMV) can cause hepatitis, encephalomyelitis, and pneumonitis in immunocompromised patients.
In contrast, CMV infection of immunocompetent patients can lead to the development of infectious mononucleosis and is typically self-limiting; severe complications are rare.
We evaluated the pathophysiology and immunological aspects of CMV hepatitis in recently immunocompetent adult patients.
Methods.
We examined the clinical features and outcomes of 47 adult immunocompetent patients with CMV hepatitis (29 men, 18 women; mean age, 34 ± 11 years) from January 2005 to August 2019 treated in our hospital.
We also assayed T-cell activation to evaluate the immune responses in these patients.
Results.
Fever (74.5%), hepatosplenomegaly (74.5%), sore throat (36.2%), headache (31.9%), abdominal pain (27.7%), lymphadenopathy (23.4%), and skin rash (6.4%) were present at admission.
Complications included gastrointestinal injury (25.5%), neuropathy (4.3%), thrombocytopenia (2.1%), and splenic infarction (2.1%).
All patients had a good clinical course without liver failure or transition to chronic liver injury.
The time to recover from liver injury ranged from 12 to 142 days (mean, 43.4 ± 28.7 days).
The serum sIL-2R level, which reflects T-cell activation, was transiently elevated and correlated with the extent of hepatic inflammation.
Conclusions.
CMV hepatitis in immunocompetent individuals has a satisfactory outcome, but occasionally results in complications in other organs.
The sIL-2R level has potential as a surrogate marker of hepatic inflammation in immunocompetent patients with CMV hepatitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Komura, Takuya& Kagaya, Takashi& Takayama, Hideo& Yanagi, Masahiro& Yoshio, Takatoshi& Sugimoto, Saiho…[et al.]. 2020. Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1139066
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Komura, Takuya…[et al.]. Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1139066
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Komura, Takuya& Kagaya, Takashi& Takayama, Hideo& Yanagi, Masahiro& Yoshio, Takatoshi& Sugimoto, Saiho…[et al.]. Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1139066
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139066
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر