The Clinical Significance of High Antimicrobial Resistance in Community-Acquired Urinary Tract Infections
المؤلفون المشاركون
Segura-Cobos, Midrori
Gonzalez, Ricardo
Zavala-Trujillo, Isidro G.
Navarro-Perez, Silvia F.
Rueda-Cruz, Jose A.
Satoscoy-Tovar, Fernando A.
Zavala-Cerna, María Guadalupe
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Urinary tract infections (UTIs) affect up to 150 million individuals annually worldwide, mainly due to Escherichia coli (E.
coli) and Klebsiella.
The emergence and spread of multidrug-resistant (MDR) bacteria are increasing, representing one of the biggest threats for human health.
The objective of our study was to describe antimicrobial patterns of resistance and identify risk factors associated with MDR uropathogens.
Methods.
We conducted a cross-sectional study in 296 patients with community-acquired UTI who underwent clinical and microbiologic analysis, and clinical associations to MDR uropathogens were investigated.
Findings.
Microbiological analysis included E.
coli (55%), ESBL-E.
coli (26%), Enterococcus (6%), Klebsiella (5%), and others (8%).
Higher frequencies of MDR bacteria were found among ESBL-E.
coli, with resistance to ampicillin (100%), ceftriaxone (96%), gentamicin (57%), ciprofloxacin (89%), and TMP/SMX (53%).
However, they were sensitive to fosfomycin (6.6%), nitrofurantoin (1.3%), and carbapenems (0%).
Fosfomycin MIC90 for ESBL-E.
coli was 5.78 μg/mL.
The only clinical variable with significant association to ESBL producers was the presence of comorbidities: hypertension and type 2 diabetes mellitus with an OR (95%CI) of 2.51.3−4.9p<0.01 and 2.81.2−6.7p<0.05, respectively.
Conclusions.
In the majority of cases, resistance rates to commonly prescribed antimicrobials in UTIs were high, except for fosfomycin, nitrofurantoin, and carbapenems.
To provide appropriate treatment, both the identification of risk factors and the uropathogen would be important.
An active surveillance in UTIs in the community is required since the proportion of ESBL producers is increasing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zavala-Cerna, María Guadalupe& Segura-Cobos, Midrori& Gonzalez, Ricardo& Zavala-Trujillo, Isidro G.& Navarro-Perez, Silvia F.& Rueda-Cruz, Jose A.…[et al.]. 2020. The Clinical Significance of High Antimicrobial Resistance in Community-Acquired Urinary Tract Infections. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1139116
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zavala-Cerna, María Guadalupe…[et al.]. The Clinical Significance of High Antimicrobial Resistance in Community-Acquired Urinary Tract Infections. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1139116
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zavala-Cerna, María Guadalupe& Segura-Cobos, Midrori& Gonzalez, Ricardo& Zavala-Trujillo, Isidro G.& Navarro-Perez, Silvia F.& Rueda-Cruz, Jose A.…[et al.]. The Clinical Significance of High Antimicrobial Resistance in Community-Acquired Urinary Tract Infections. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1139116
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139116
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر