Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response
المؤلفون المشاركون
Davidová, Alžběta
Arientová, Simona
Roubalová, Kateřina
Chalupa, Pavel
Beran, Ondřej
Holub, Michal
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
Genital herpes simplex virus (HSV) infection is controlled by HSV-specific T cells in the genital tract, and the role of systemic T cell responses is not fully understood.
Thus, we analysed T cell responses in patients with recurrent genital herpes (GH).
Methods.
T cell responses to HSV-1 and HSV-2 native antigens and the expression of HLA-DR and CD38 molecules on circulating CD8+ T cells were analysed in adults with high frequency of GH recurrences (19 patients) and low frequency of GH recurrences (7 patients) and 12 HSV-2 seronegative healthy controls.
The study utilized the interferon-γ Elispot assay for measurement of spot-forming cells (SFC) after ex vivo stimulation with HSV antigens and flow cytometry for analysis of the expression of activation markers in unstimulated T cells.
Results.
The patients with high frequency of GH recurrences (mean number of recurrences of 13.3 per year) had significantly enhanced HSV-specific T cell responses than the HSV-2 seronegative healthy controls.
Moreover, a trend of higher numbers of SFC was observed in these patients when compared with those with low frequency of GH recurrences (mean number of recurrences of 3.3 per year).
Additionally, no differences in CD38 and HLA-DR expression on circulating CD8+ T cells were found among the study groups.
Conclusions.
Frequency of GH recurrences positively correlates with high numbers of systemic HSV-specific T cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Holub, Michal& Davidová, Alžběta& Chalupa, Pavel& Arientová, Simona& Roubalová, Kateřina& Beran, Ondřej. 2020. Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1139142
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holub, Michal…[et al.]. Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1139142
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Holub, Michal& Davidová, Alžběta& Chalupa, Pavel& Arientová, Simona& Roubalová, Kateřina& Beran, Ondřej. Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1139142
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139142
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر