The Impact of Age and Pathogens Type on the Gut Microbiota in Infants with Diarrhea in Dalian, China
المؤلفون المشاركون
Yi, Ming
Liu, He
Yuan, Jieli
Fan, Qingjie
Wang, Yushuang
Li, Xinke
Hou, Binbin
Li, Ming
Wang, Lili
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
Diarrhea in infants is a serious gastrointestinal dysfunction characterized by vomiting and watery bowel movements.
Without proper treatment, infants will develop a dangerous electrolyte imbalance.
Diarrhea is accompanied by intestinal dysbiosis.
This study compared the gut microbiota between healthy infants and diarrheic infants.
It also investigated the effects of age and pathogen type on the gut microbiota of infants with diarrhea, providing data for the proper treatment for diarrhea in infants.
Materials and Methods.
DNA was collected from the fecal samples of 42 Chinese infants with diarrhea and 37 healthy infants.
The healthy infants and infants with diarrhea were divided into four age groups: 0–120, 120–180, 180–270, and 270–365 days.
Using PCR and 16S rRNA high-throughput sequencing, the diarrhea-causing pathogens in these infants were identified and then categorized into four groups: Salmonella infection, Staphylococcus aureus infection, combined Salmonella and Staphylococcus aureus infection, and others (neither Salmonella nor Staphylococcus aureus).
Results.
The species diversity of gut microbiota in diarrheic infants was significantly reduced compared with that in healthy infants.
Infants with diarrhea had a lower abundance of Lactobacillus spp.
and Bacillus spp.
(P<0.001) and a significant richness of Klebsiella spp.
and Enterobacter spp.
(P<0.001).
Similar gut microbiota patterns were found in diarrheic infants in all four age groups.
However, different pathogenic infections have significant effects on the gut microbiota of diarrheic infants.
For instance, the relative abundance of Klebsiella spp.
and Streptococcus spp.
was significantly increased (P<0.001) in infants infected with Staphylococcus aureus; meanwhile, the richness of bacteria such as Enterobacter spp.
was significantly increased in the Salmonella infection group (P<0.001).
Conclusion.
The microbiota in infants with diarrhea has changed significantly, characterized by decreased species diversity and abundance of beneficial bacteria and significant increase in the proportion of conditional pathogens.
Meanwhile, the gut microbiota of infants with diarrhea at different ages was similar, but different pathogenic infections affect the gut microbiota characteristics.
Therefore, early identification of changes in gut microbiota in infants with diarrhea and the adoption of appropriate pathogen type-specific interventions may effectively alleviate the disease and reduce adverse reactions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Qingjie& Yi, Ming& Liu, He& Wang, Yushuang& Li, Xinke& Yuan, Jieli…[et al.]. 2020. The Impact of Age and Pathogens Type on the Gut Microbiota in Infants with Diarrhea in Dalian, China. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1139191
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Qingjie…[et al.]. The Impact of Age and Pathogens Type on the Gut Microbiota in Infants with Diarrhea in Dalian, China. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1139191
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Qingjie& Yi, Ming& Liu, He& Wang, Yushuang& Li, Xinke& Yuan, Jieli…[et al.]. The Impact of Age and Pathogens Type on the Gut Microbiota in Infants with Diarrhea in Dalian, China. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1139191
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139191
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر