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Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches
المؤلفون المشاركون
Guerra-Araiza, Christian
Pinto-Almazán, Rodolfo
Segura-Uribe, Julia J.
Farfán-García, Eunice D.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hormone replacement therapy (HRT) increases the risk of endometrial and breast cancer.
A strategy to reduce this incidence is the use of tibolone (TIB).
The aim of this paper was to address the effects of TIB on the central nervous system (CNS).
For the present review, MEDLINE (via PubMed), LILACS (via BIREME), Ovid Global Health, SCOPUS, Scielo, and PsycINFO (ProQuest Research Library) electronic databases were searched for the results of controlled clinical trials on peri- and postmenopausal women published from 1990 to September 2016.
Also, this paper reviews experimental studies performed to analyze neuroprotective effects, cognitive deficits, neuroplasticity, oxidative stress, and stroke using TIB.
Although there are few studies on the effect of this hormone in the CNS, it has been reported that TIB decreases lipid peroxidation levels and improves memory and learning.
TIB has important neuroprotective effects that could prevent the risk of neurodegenerative diseases in postmenopausal women as well as the benefits of HRT in counteracting hot flashes, improving mood, and libido.
Some reports have found that TIB delays cognitive impairment in various models of neuronal damage.
It also modifies brain plasticity since it acts as an endocrine modulator regulating neurotransmitters, Tau phosphorylation, and decreasing neuronal death.
Finally, its antioxidant effects have also been reported in different animal models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pinto-Almazán, Rodolfo& Segura-Uribe, Julia J.& Farfán-García, Eunice D.& Guerra-Araiza, Christian. 2017. Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pinto-Almazán, Rodolfo…[et al.]. Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pinto-Almazán, Rodolfo& Segura-Uribe, Julia J.& Farfán-García, Eunice D.& Guerra-Araiza, Christian. Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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