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99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans
المؤلفون المشاركون
García-Perez, Osvaldo
Ferro-Flores, Guillermina
Santos-Cuevas, Clara
Azorín-Vega, Erika
Luna-Gutiérrez, Myrna
Vallejo-Armenta, Paola
Soto-Andonaegui, Juan
Villanueva-Pérez, Rosa M.
González-Díaz, Jorge I.
Arrellano-Zarate, Angélica
Ocampo-García, Blanca
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness.
Recently, we reported the preclinical evaluation of 99mTc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-99mTc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specifically detecting the CXCR4 protein.
This research aimed to estimate the biokinetic behavior and radiation dosimetry of 99mTc-CXCR4-L in healthy subjects, as well as to correlate the radiotracer uptake by brain tumors in patients, with the histological grade of differentiation and CXCR4 expression evaluated by immunohistochemistry.
99mTc-CXCR4-L was obtained from freeze-dried kits prepared under GMP conditions (radiochemical purities >97%).
Whole-body scans from six healthy volunteers were acquired at 0.3, 1, 2, 4, 6, and 24 h after 99mTc-CXCR4-L administration (0.37 GBq).
Time-activity curves of different source organs were obtained from the image sequence to adjust the biokinetic models.
The OLINDA/EXM code was employed to calculate the equivalent and effective radiation doses.
Nine patients with evidence of brain tumor injury (6 primaries and 3 recurrent), determined by MRI, underwent cerebral SPECT at 3 h after administration of 99mTc-CXCR4-L (0.74 GBq).
Data were expressed as a T/B (tumor uptake/background) ratio.
Biopsy examinations included histological grading and anti-CXCR4 immunohistochemistry.
Results showed a fast blood activity clearance (T1/2α = 0.81 min and T1/2β = 12.19 min) with renal and hepatobiliary elimination.
The average equivalent doses were 6.10E − 04, 1.41E − 04, and 3.13E − 05 mSv/MBq for the intestine, liver, and kidney, respectively.
The effective dose was 3.92E − 03 mSv/MBq.
SPECT was positive in 7/9 patients diagnosed as grade II oligodendroglioma (two patients), grade IV glioblastoma (two patients), grade IV gliosarcoma (one patient), metastasis, and diffuse astrocytoma with T/B ratios of 1.3, 2.3, 13, 7, 19, 5.5, and 3.9, respectively, all of them with positive immunohistochemistry.
A direct relationship between the grade of differentiation and the expression of CXCR4 was found.
The two negative SPECT studies showed negative immunohistochemistry with a diagnosis of reactive gliosis.
This “proof-of-concept” research warrants further clinical studies to establish the usefulness of 99mTc-CXCR4-L in the diagnosis and prognosis of brain tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vallejo-Armenta, Paola& Santos-Cuevas, Clara& Soto-Andonaegui, Juan& Villanueva-Pérez, Rosa M.& González-Díaz, Jorge I.& García-Perez, Osvaldo…[et al.]. 2020. 99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans. Contrast Media & Molecular Imaging،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1139233
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vallejo-Armenta, Paola…[et al.]. 99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans. Contrast Media & Molecular Imaging No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1139233
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vallejo-Armenta, Paola& Santos-Cuevas, Clara& Soto-Andonaegui, Juan& Villanueva-Pérez, Rosa M.& González-Díaz, Jorge I.& García-Perez, Osvaldo…[et al.]. 99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans. Contrast Media & Molecular Imaging. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1139233
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139233
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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