A Noninvasive Score Model for Prediction of NASH in Patients with Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease

المؤلفون المشاركون

Gao, Ying-tang
Jing, Li
Han, Tao
Liang, Jing
Liu, Fang
Wang, Fengmei
Ma, Zhe

المصدر

BioMed Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-03-02

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Aims.

To develop a noninvasive score model to predict NASH in patients with combined CHB and NAFLD.

Objective and Methods.

65 CHB patients with NAFLD were divided into NASH group (34 patients) and non-NASH group (31 patients) according to the NAS score.

Biochemical indexes, liver stiffness, and Controlled Attenuation Parameter (CAP) were determined.

Data in the two groups were compared and subjected to multivariate analysis, to establish a score model for the prediction of NASH.

Results.

In the NASH group, ALT, TG, fasting blood glucose (FBG), M30 CK-18, CAP, and HBeAg positive ratio were significantly higher than in the non-NASH group (P<0.05).

Multivariate analysis showed that CK-18 M30, CAP, FBG, and HBVDNA level were independent predictors of NASH.

Therefore, a new model combining CK18 M30, CAP, FBG, and HBVDNA level was established using logistic regression.

The AUROC curve predicting NASH was 0.961 (95% CI: 0.920–1.00, cutoff value is 0.218), with a sensitivity of 100% and specificity of 80.6%.

Conclusion.

A noninvasive score model might be considered for the prediction of NASH in patients with CHB combined with NAFLD.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liang, Jing& Liu, Fang& Wang, Fengmei& Han, Tao& Jing, Li& Ma, Zhe…[et al.]. 2017. A Noninvasive Score Model for Prediction of NASH in Patients with Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139275

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liang, Jing…[et al.]. A Noninvasive Score Model for Prediction of NASH in Patients with Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139275

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liang, Jing& Liu, Fang& Wang, Fengmei& Han, Tao& Jing, Li& Ma, Zhe…[et al.]. A Noninvasive Score Model for Prediction of NASH in Patients with Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139275

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1139275