Iron (III)‎-Quercetin Complex: Synthesis, Physicochemical Characterization, and MRI Cell Tracking toward Potential Applications in Regenerative Medicine

المؤلفون المشاركون

Papan, Phakorn
Kantapan, Jiraporn
Sangthong, Padchanee
Meepowpan, Puttinan
Dechsupa, Nathupakorn

المصدر

Contrast Media & Molecular Imaging

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-22، 22ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-12-29

دولة النشر

مصر

عدد الصفحات

22

الموضوع الرئيسي

الأمراض
الطب البشري

الملخص EN

In cell therapy, contrast agents T1 and T2 are both needed for the labeling and tracking of transplanted stem cells over extended periods of time through magnetic resonance imaging (MRI).

Importantly, the metal-quercetin complex via coordination chemistry has been studied extensively for biomedical applications, such as anticancer therapies and imaging probes.

Herein, we report on the synthesis, characterization, and labeling of the iron (III)-quercetin complex, “IronQ,” in circulating proangiogenic cells (CACs) and also explore tracking via the use of a clinical 1.5 Tesla (T) MRI scanner.

Moreover, IronQ had a paramagnetic T1 positive contrast agent property with a saturation magnetization of 0.155 emu/g at 1.0 T and longitudinal relaxivity (r1) values of 2.29 and 3.70 mM−1s−1 at 1.5 T for water and human plasma, respectively.

Surprisingly, IronQ was able to promote CAC growth in conventional cell culture systems without the addition of specific growth factors.

Increasing dosages of IronQ from 0 to 200 μg/mL led to higher CAC uptake, and maximum labeling time was achieved in 10 days.

The accumulated IronQ in CACs was measured by two methodologies, an inductively coupled plasma optical emission spectrometry (ICP-EOS) and T1-weighted MRI.

In our research, we confirmed that IronQ has excellent dual functions with the use of an imaging probe for MRI.

IronQ can also act as a stimulating agent by favoring circulating proangiogenic cell differentiation.

Optimistically, IronQ is considered beneficial for alternative labeling and in the tracking of circulation proangiogenic cells and/or other stem cells in applications of cell therapy through noninvasive magnetic resonance imaging in both preclinical and clinical settings.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Papan, Phakorn& Kantapan, Jiraporn& Sangthong, Padchanee& Meepowpan, Puttinan& Dechsupa, Nathupakorn. 2020. Iron (III)-Quercetin Complex: Synthesis, Physicochemical Characterization, and MRI Cell Tracking toward Potential Applications in Regenerative Medicine. Contrast Media & Molecular Imaging،Vol. 2020, no. 2020, pp.1-22.
https://search.emarefa.net/detail/BIM-1139279

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Papan, Phakorn…[et al.]. Iron (III)-Quercetin Complex: Synthesis, Physicochemical Characterization, and MRI Cell Tracking toward Potential Applications in Regenerative Medicine. Contrast Media & Molecular Imaging No. 2020 (2020), pp.1-22.
https://search.emarefa.net/detail/BIM-1139279

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Papan, Phakorn& Kantapan, Jiraporn& Sangthong, Padchanee& Meepowpan, Puttinan& Dechsupa, Nathupakorn. Iron (III)-Quercetin Complex: Synthesis, Physicochemical Characterization, and MRI Cell Tracking toward Potential Applications in Regenerative Medicine. Contrast Media & Molecular Imaging. 2020. Vol. 2020, no. 2020, pp.1-22.
https://search.emarefa.net/detail/BIM-1139279

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1139279