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An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos
المؤلفون المشاركون
Lee, Wenqing Jean
Chatterjee, Sumantra
Yap, Sook Peng
Lim, Siew Lan
Xing, Xing
Kraus, Petra
Sun, Wenjie
Hu, Xiaoming
Sivakamasundari, V.
Chan, Hsiao Yun
Kolatkar, Prasanna R.
Prabhakar, Shyam
Lufkin, Thomas
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-28
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Embryogenesis is an intricate process involving multiple genes and pathways.
Some of the key transcription factors controlling specific cell types are the Sox trio, namely, Sox5, Sox6, and Sox9, which play crucial roles in organogenesis working in a concerted manner.
Much however still needs to be learned about their combinatorial roles during this process.
A developmental genomics and systems biology approach offers to complement the reductionist methodology of current developmental biology and provide a more comprehensive and integrated view of the interrelationships of complex regulatory networks that occur during organogenesis.
By combining cell type-specific transcriptome analysis and in vivo ChIP-Seq of the Sox trio using mouse embryos, we provide evidence for the direct control of Sox5 and Sox6 by the transcriptional trio in the murine model and by Morpholino knockdown in zebrafish and demonstrate the novel role of Tgfb2, Fbxl18, and Tle3 in formation of Sox5, Sox6, and Sox9 dependent tissues.
Concurrently, a complete embryonic gene regulatory network has been generated, identifying a wide repertoire of genes involved and controlled by the Sox trio in the intricate process of normal embryogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Wenqing Jean& Chatterjee, Sumantra& Yap, Sook Peng& Lim, Siew Lan& Xing, Xing& Kraus, Petra…[et al.]. 2017. An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. BioMed Research International،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1139287
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Wenqing Jean…[et al.]. An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. BioMed Research International No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1139287
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Wenqing Jean& Chatterjee, Sumantra& Yap, Sook Peng& Lim, Siew Lan& Xing, Xing& Kraus, Petra…[et al.]. An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1139287
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139287
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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