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Preimplantation Genetic Diagnosis for Myotonic Dystrophy Type 1 and Analysis of the Effect of the Disease on the Reproductive Outcome of the Affected Female Patients
المؤلفون المشاركون
García-Lozano, Juan Carlos
Peciña, Ana
Antiñolo, Guillermo
Lozano-Arana, Maria Dolores
Borrego, Salud
Sánchez, Beatriz
Fernández, Raquel María
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Myotonic dystrophy type 1 (DM1) is the most common adult muscular dystrophy and presents an autosomal dominant inheritance.
A reproductive option for the families affected is preimplantation genetic diagnosis (PGD).
One limitation of this option is the nonoptimal response to ovarian stimulation of the women with DM1, although controversial results exist regarding this subject.
In this study, we have analyzed the results of the PGD program applied to DM1 at our institution.
A total of 35 couples have been included in our program since 2010, and 59 cycles have been performed.
The percentage of transfers per cycle was 64.4% and the live birth rate per cycle was 18.6%.
Interestingly, statistically significant differences were observed for the clinical results in the group of couples with an affected female versus the group with an affected male or versus a group of couples with different referral reasons.
Specifically, both the percentage of mature oocytes out of the total oocytes retrieved and the percentage of fertilization were considerably lower in the group of DM1 females.
Our findings would suggest the possibility of achieving less favourable PGD outcomes in women with DM1 in comparison with other pathologies, although the underlying mechanism remains unknown.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fernández, Raquel María& Lozano-Arana, Maria Dolores& Sánchez, Beatriz& Peciña, Ana& García-Lozano, Juan Carlos& Borrego, Salud…[et al.]. 2017. Preimplantation Genetic Diagnosis for Myotonic Dystrophy Type 1 and Analysis of the Effect of the Disease on the Reproductive Outcome of the Affected Female Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fernández, Raquel María…[et al.]. Preimplantation Genetic Diagnosis for Myotonic Dystrophy Type 1 and Analysis of the Effect of the Disease on the Reproductive Outcome of the Affected Female Patients. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fernández, Raquel María& Lozano-Arana, Maria Dolores& Sánchez, Beatriz& Peciña, Ana& García-Lozano, Juan Carlos& Borrego, Salud…[et al.]. Preimplantation Genetic Diagnosis for Myotonic Dystrophy Type 1 and Analysis of the Effect of the Disease on the Reproductive Outcome of the Affected Female Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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