miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2ARE Signaling Pathway
المؤلفون المشاركون
Miao, Ying
Wan, Qin
Liu, Xiaoyu
Wang, Yu
Luo, Yi
Liu, Dan
Lin, Nengbo
Zhou, Honggang
Zhong, Jiyuan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diabetic cardiomyopathy (DCM) is a common heart disease.
The Phase II enzyme inducer (CPDT) is a complex enzyme that promotes the expression of antioxidant enzymes through activating nuclear factor erythroid 2-related factor 2 (Nrf2); these compounds have been shown to protect against oxidative stress.
However, whether these compounds have similar protective effects in DCM still remains unclear.
The purpose of this study is to investigate the protective effects and potential mechanism of CPDT in diabetic cardiomyopathy.
In the results, firstly, compared with control rats, myocardial cell size, left ventricular mass index, and myocardial apoptosis index were increased, miR-503 was increased, and Nrf2, malondialdehyde (MDA), and heme oxygenase 1 (HO-1) were decreased in diabetic cardiomyopathy rats.
Furthermore, compared with diabetic cardiomyopathy rats, these above parameters show the opposite change in CPDT treatment rats.
In addition, the bioinformatics and luciferase reporter assay demonstrated that Nrf2 is a direct target of miR-503.
Finally, the miR-503 could also regulate Nrf2 in the myocardial cells.
Therefore, miR-503 is involved in the protective effect of CPDT in diabetic cardiomyopathy via Nrf2/ARE signaling pathway; miR-503 and Nrf2 may be a promising therapeutic target for the management of diabetic cardiomyopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miao, Ying& Wan, Qin& Liu, Xiaoyu& Wang, Yu& Luo, Yi& Liu, Dan…[et al.]. 2017. miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2ARE Signaling Pathway. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139383
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miao, Ying…[et al.]. miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2ARE Signaling Pathway. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139383
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miao, Ying& Wan, Qin& Liu, Xiaoyu& Wang, Yu& Luo, Yi& Liu, Dan…[et al.]. miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2ARE Signaling Pathway. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139383
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139383
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر