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Natural Scaffolds for Regenerative Medicine: Direct Determination of Detergents Entrapped in Decellularized Heart Valves
المؤلفون المشاركون
Dettin, Monica
Zamuner, Annj
Naso, Filippo
Monteleone, Antonella
Spina, Michele
Gerosa, Gino
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The increasing urgency for replacement of pathological heart valves is a major stimulus for research on alternatives to glutaraldehyde-treated grafts.
New xenogeneic acellular heart valve substitutes that can be repopulated by host cells are currently under investigation.
Anionic surfactants, including bile acids, have been widely used to eliminate the resident cell components chiefly responsible for the immunogenicity of the tissue, even if detergent toxicity might present limitations to the survival and/or functional expression of the repopulating cells.
To date, the determination of residual detergent has been carried out almost exclusively on the washings following cell removal procedures.
Here, a novel HPLC-based procedure is proposed for the direct quantification of detergent (cholate, deoxycholate, and taurodeoxycholate) residues entrapped in the scaffold of decellularized porcine aortic and pulmonary valves.
The method was demonstrated to be sensitive, reproducible, and extendable to different types of detergent.
This assessment also revealed that cell-depleted heart valve scaffolds prepared according to procedures currently considered for clinical use might contain significant amount of surfactant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dettin, Monica& Zamuner, Annj& Naso, Filippo& Monteleone, Antonella& Spina, Michele& Gerosa, Gino. 2017. Natural Scaffolds for Regenerative Medicine: Direct Determination of Detergents Entrapped in Decellularized Heart Valves. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dettin, Monica…[et al.]. Natural Scaffolds for Regenerative Medicine: Direct Determination of Detergents Entrapped in Decellularized Heart Valves. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dettin, Monica& Zamuner, Annj& Naso, Filippo& Monteleone, Antonella& Spina, Michele& Gerosa, Gino. Natural Scaffolds for Regenerative Medicine: Direct Determination of Detergents Entrapped in Decellularized Heart Valves. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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