Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the ProliferativeApoptotic Index
المؤلفون المشاركون
Kumar, Shiyam
Al-Bahlani, Shadia
Al-Rashdi, Ruqaya M.
Al-Sinawi, Shadia S.
Al-Bahri, Maiya A.
Shalaby, Asem A.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer in which calpain system plays an important role in its cellular processes including apoptosis and proliferation.
Although such roles have been assessed in tumor pathogenesis, the correlation of its expression to the proliferating/apoptotic index has not been studied yet.
Immunohistochemical staining of calpain-1 was performed on paraffin-embedded tissues to correlate its expression with clinicopathological variables and outcome.
The proliferation activity was determined by calculating the percentage of cells expressing the Ki-67 antigen.
The apoptotic index was assessed morphologically and biochemically using Haematoxylin & Eosin method and Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, respectively.
Calpain-1 was significantly expressed in TNBC tissues varying from low to high with a significant correlation to lymph node status but not with the other clinicopathological variables, suggesting its role as a prognostic factor.
In addition, a positive correlation was found between both apoptotic counts assays (P<0.001, r=0.547) as well as with proliferation (P=0.045).
Calpain-1 expression had no significant correlation with either proliferation (P=0.29) or apoptotic indices (P=0.071 and P=0.100).
Determining calpain-1 expression may provide relevant prognostic value for TNBC cancer patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Bahlani, Shadia& Al-Rashdi, Ruqaya M.& Kumar, Shiyam& Al-Sinawi, Shadia S.& Al-Bahri, Maiya A.& Shalaby, Asem A.. 2017. Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the ProliferativeApoptotic Index. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139448
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Bahlani, Shadia…[et al.]. Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the ProliferativeApoptotic Index. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139448
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Bahlani, Shadia& Al-Rashdi, Ruqaya M.& Kumar, Shiyam& Al-Sinawi, Shadia S.& Al-Bahri, Maiya A.& Shalaby, Asem A.. Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the ProliferativeApoptotic Index. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139448
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139448
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر