CUL1-Mediated Organelle Fission Pathway Inhibits the Development of Chronic Obstructive Pulmonary Disease
المؤلفون المشاركون
Li, Ran
Xu, Feng
Wu, Xiao
Ji, Shaoping
Xia, Ruixue
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Chronic obstructive pulmonary disease (COPD) is a global high-incidence chronic airway inflammation disease.
Its deterioration will lead to more serious lung lesions and even lung cancer.
Therefore, it is urgent to determine the pathogenesis of COPD and find potential therapeutic targets.
The purpose of this study is to reveal the molecular mechanism of COPD disease development through in-depth analysis of transcription factors and ncRNA-driven pathogenic modules of COPD.
We obtained the expression profile of COPD-related microRNAs from the NCBI-GEO database and analyzed the differences among groups to identify the microRNAs significantly associated with COPD.
Then, their target genes are predicted and mapped to a protein-protein interaction (PPI) network.
Finally, key transcription factors and the ncRNA of the regulatory module were identified based on the hypergeometric test.
The results showed that CUL1 was the most interactive gene in the highly interactive module, so it was recognized as a dysfunctional molecule of COPD.
Enrichment analysis also showed that it was much involved in the biological process of organelle fission, the highest number of regulatory modules.
In addition, ncRNAs, mainly composed of miR-590-3p, miR-495-3p, miR-186-5p, and transcription factors such as MYC, BRCA1, and CDX2, significantly regulate COPD dysfunction blocks.
In summary, we revealed that the COPD-related target gene CUL1 plays a key role in the potential dysfunction of the disease.
It promotes the proliferation of fibroblast cells in COPD patients by mediating functional signals of organelle fission and thus participates in the progress of the disease.
Our research helps biologists to further understand the etiology and development trend of COPD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Ran& Xu, Feng& Wu, Xiao& Ji, Shaoping& Xia, Ruixue. 2020. CUL1-Mediated Organelle Fission Pathway Inhibits the Development of Chronic Obstructive Pulmonary Disease. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139473
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Ran…[et al.]. CUL1-Mediated Organelle Fission Pathway Inhibits the Development of Chronic Obstructive Pulmonary Disease. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1139473
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Ran& Xu, Feng& Wu, Xiao& Ji, Shaoping& Xia, Ruixue. CUL1-Mediated Organelle Fission Pathway Inhibits the Development of Chronic Obstructive Pulmonary Disease. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139473
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139473
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر