Discovery of Prognostic Signature Genes for Overall Survival Prediction in Gastric Cancer
المؤلفون المشاركون
Meng, Changyuan
Xia, Shusen
He, Yi
Tang, Xiaolong
Zhang, Guangjun
Zhou, Tong
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Gastric cancer (GC) is one of the most common malignant tumors in the digestive system with high mortality globally.
However, the biomarkers that accurately predict the prognosis are still lacking.
Therefore, it is important to screen for novel prognostic markers and therapeutic targets.
Methods.
We conducted differential expression analysis and survival analysis to screen out the prognostic genes.
A stepwise method was employed to select a subset of genes in the multivariable Cox model.
Overrepresentation enrichment analysis (ORA) was used to search for the pathways associated with poor prognosis.
Results.
In this study, we designed a seven-gene-signature-based Cox model to stratify the GC samples into high-risk and low-risk groups.
The survival analysis revealed that the high-risk and low-risk groups exhibited significantly different prognostic outcomes in both the training and validation datasets.
Specifically, CGB5, IGFBP1, OLFML2B, RAI14, SERPINE1, IQSEC2, and MPND were selected by the multivariable Cox model.
Functionally, PI3K-Akt signaling pathway and platelet-derived growth factor receptor (PDGFR) were found to be hyperactive in the high-risk group.
The multivariable Cox regression analysis revealed that the risk stratification based on the seven-gene-signature-based Cox model was independent of other prognostic factors such as TNM stages, age, and gender.
Conclusion.
In conclusion, we aimed at developing a model to predict the prognosis of gastric cancer.
The predictive model could not only effectively predict the risk of GC but also be beneficial to the development of therapeutic strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Changyuan& Xia, Shusen& He, Yi& Tang, Xiaolong& Zhang, Guangjun& Zhou, Tong. 2020. Discovery of Prognostic Signature Genes for Overall Survival Prediction in Gastric Cancer. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139478
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Changyuan…[et al.]. Discovery of Prognostic Signature Genes for Overall Survival Prediction in Gastric Cancer. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1139478
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Changyuan& Xia, Shusen& He, Yi& Tang, Xiaolong& Zhang, Guangjun& Zhou, Tong. Discovery of Prognostic Signature Genes for Overall Survival Prediction in Gastric Cancer. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139478
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139478
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر