MMP-2, MMP-9, and TIMP-4 and Response to Aspirin in Diabetic and Nondiabetic Patients with Stable Coronary Artery Disease: A Pilot Study
المؤلفون المشاركون
Bil-Lula, Iwona
Kuliczkowski, Wiktor
Radomski, Marek
Gąsior, Mariusz
Urbaniak, Joanna
Kaczmarski, Jacek
Mysiak, Andrzej
Negrusz-Kawecka, Marta
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
High on-aspirin treatment platelets reactivity (HPR) is a significant problem in long-term secondary prevention of cardiovascular events.
We hypothesize that imbalance between platelets MMPs/TIMPs results in cardiovascular disorders.
We also explored whether chronically elevated blood glucose affects MMP-2/TIMP-4 release from platelets.
Materials and Methods.
Seventy patients with stable coronary artery disease, supplemented with aspirin, participated in this pilot study.
The presence of HPR and/or diabetes mellitus was considered as the differentiating factor.
Light aggregometry, impedance aggregometry, and ELISA tests for TXB2, MMP-2, MMP-9, and TIMP-4 were performed in serum, plasma, platelet-rich plasma, and platelets-poor plasma, as appropriate.
Results.
Aspirin-HPR did not affect plasma MMP-2, MMP-9, and TIMP-4.
Arachidonic acid-induced aggregation of platelets from aspirin-HPR patients did not lead to increased release of MMP-2, MMP-9, and TIMP-4.
Studying patients at the lowest TXB2 serum concentration quartile revealed that high concentration of plasma TIMP-4 and TIMP-4 negatively correlated with TXB2 and platelet aggregation.
Diabetics showed an increased plasma MMP-2 as well as an increased MMP-2 in supernatants after platelet aggregation.
However, diabetes mellitus did not affect MMP-9 and TIMP-4.
Conclusion.
Aspirin-HPR did not affect the translocation and release of MMPs and TIMP-4 from platelets.
TIMP-4 may serve as a marker of TXA2-mediated platelet aggregation.
Chronically elevated plasma glucose increases plasma MMP-2, and HPR potentiates this phenomenon.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuliczkowski, Wiktor& Radomski, Marek& Gąsior, Mariusz& Urbaniak, Joanna& Kaczmarski, Jacek& Mysiak, Andrzej…[et al.]. 2017. MMP-2, MMP-9, and TIMP-4 and Response to Aspirin in Diabetic and Nondiabetic Patients with Stable Coronary Artery Disease: A Pilot Study. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139491
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuliczkowski, Wiktor…[et al.]. MMP-2, MMP-9, and TIMP-4 and Response to Aspirin in Diabetic and Nondiabetic Patients with Stable Coronary Artery Disease: A Pilot Study. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1139491
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuliczkowski, Wiktor& Radomski, Marek& Gąsior, Mariusz& Urbaniak, Joanna& Kaczmarski, Jacek& Mysiak, Andrzej…[et al.]. MMP-2, MMP-9, and TIMP-4 and Response to Aspirin in Diabetic and Nondiabetic Patients with Stable Coronary Artery Disease: A Pilot Study. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139491
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139491
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر