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Holistic View on Cell Survival and DNA Damage: How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems
المؤلفون المشاركون
Weyland, Mathias S.
Thumser-Henner, Pauline
Nytko, Katarzyna J.
Rohrer Bley, Carla
Ulzega, Simone
Petri-Fink, Alke
Lattuada, Marco
Füchslin, Rudolf M.
Scheidegger, Stephan
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
In this work, a method is established to calibrate a model that describes the basic dynamics of DNA damage and repair.
The model can be used to extend planning for radiotherapy and hyperthermia in order to include the biological effects.
In contrast to “syntactic” models (e.g., describing molecular kinetics), the model used here describes radiobiological semantics, resulting in a more powerful model but also in a far more challenging calibration.
Model calibration is attempted from clonogenic assay data (doses of 0–6 Gy) and from time-resolved comet assay data obtained within 6 h after irradiation with 6 Gy.
It is demonstrated that either of those two sources of information alone is insufficient for successful model calibration, and that both sources of information combined in a holistic approach are necessary to find viable model parameters.
Approximate Bayesian computation (ABC) with simulated annealing is used for parameter search, revealing two aspects that are beneficial to resolving the calibration problem: (1) assessing posterior parameter distributions instead of point-estimates and (2) combining calibration runs from different assays by joining posterior distributions instead of running a single calibration run with a combined, computationally very expensive objective function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weyland, Mathias S.& Thumser-Henner, Pauline& Nytko, Katarzyna J.& Rohrer Bley, Carla& Ulzega, Simone& Petri-Fink, Alke…[et al.]. 2020. Holistic View on Cell Survival and DNA Damage: How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weyland, Mathias S.…[et al.]. Holistic View on Cell Survival and DNA Damage: How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1139499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weyland, Mathias S.& Thumser-Henner, Pauline& Nytko, Katarzyna J.& Rohrer Bley, Carla& Ulzega, Simone& Petri-Fink, Alke…[et al.]. Holistic View on Cell Survival and DNA Damage: How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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