Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network
المؤلفون المشاركون
Luo, Yi
Que, Feng
Wang, Hua
Cui, Li
Wei, Lanfu
Xi, Zhaohong
Lin, Qiu
Ge, Yongsheng
Wang, Wei
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-01
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The morbidity and mortality of colorectal cancer (CRC) remained to be very high worldwide.
Recently, circRNAs had been revealed to have a crucial role in cancer prognosis and progression.
Numerous researches have shown that RNA sequencing technology and in silico method were widely used to identify pathogenic mechanisms and uncover promising targets for diagnosis and therapy.
In this study, these methods were analyzed to obtain differentially expressed circRNAs (DECs).
We identified upregulated 316 circRNAs and reduced 76 circRNAs in CRC samples, in comparison with those in normal tissues.
In addition, a competitive endogenous network of circRNA-miRNA-mRNA was established to predict the mechanisms of circRNAs.
Bioinformatics analysis revealed that these circRNAs participated in metabolism regulation and cell cycle progression.
Of note, we observed the hub genes and miRNAs in this ceRNA network were associated with the survival time in CRC.
We think this study could provide potential prognostic biomarkers and targets for CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Que, Feng& Wang, Hua& Luo, Yi& Cui, Li& Wei, Lanfu& Xi, Zhaohong…[et al.]. 2020. Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1139548
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Que, Feng…[et al.]. Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1139548
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Que, Feng& Wang, Hua& Luo, Yi& Cui, Li& Wei, Lanfu& Xi, Zhaohong…[et al.]. Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1139548
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139548
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر