Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma

المؤلفون المشاركون

Yang, Cai
Mei, Hongxiang
Peng, Liang
Jiang, Fulin
Xie, Bingjie
Li, Juan

المصدر

Computational and Mathematical Methods in Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-23، 23ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-12-29

دولة النشر

مصر

عدد الصفحات

23

التخصصات الرئيسية

الطب البشري

الملخص EN

Considerable evidence indicates that autophagy plays a vital role in the biological processes of various cancers.

The aim of this study is to evaluate the prognostic value of autophagy-related genes in patients with head and neck squamous cell carcinoma (HNSCC).

Transcriptome expression profiles and clinical data acquired from The Cancer Genome Atlas (TCGA) database were analyzed by Cox proportional hazards model and Kaplan–Meier survival analysis to screen autophagy-related prognostic genes that were significantly correlated with HNSCC patients’ overall survival.

Functional enrichment analyses were performed to explore biological functions of differentially expressed autophagy-related genes (ARGs) identified in HNSCC patients.

Six ARGs (EGFR, HSPB8, PRKN, CDKN2A, FADD, and ITGA3) identified with significantly prognostic values for HNSCC were used to construct a risk signature that could stratify patients into the high-risk and low-risk groups.

This signature demonstrated great value in predicting prognosis for HNSCC patients and was indicated as an independent prognostic factor in terms of clinicopathological characteristics (sex, age, clinical stage, histological grade, anatomic subdivision, alcohol history, smoking status, HPV status, and mutational status of the samples).

The prognostic signature was also validated by data from the Gene Expression Omnibus (GEO) database and International Cancer Genome Consortium (ICGC).

In conclusion, this study provides a novel autophagy-related gene signature for predicting prognosis of HNSCC patients and gives molecular insights of autophagy in HNSCC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yang, Cai& Mei, Hongxiang& Peng, Liang& Jiang, Fulin& Xie, Bingjie& Li, Juan. 2020. Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1139564

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yang, Cai…[et al.]. Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-23.
https://search.emarefa.net/detail/BIM-1139564

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yang, Cai& Mei, Hongxiang& Peng, Liang& Jiang, Fulin& Xie, Bingjie& Li, Juan. Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1139564

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1139564