Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke

المؤلفون المشاركون

Zheng, Lifang
Cheng, Wei
Wang, Xijia
Yang, Zhigang
Zhou, Xiangling
Pan, Chunlian

المصدر

BioMed Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-09-13

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Cerebral ischemic stroke, which affects the global population, is a major disease with high incidence, mortality, and disability.

Accumulating evidence has indicated that abnormal microRNA (miRNA) expression plays essential roles in the pathologies of ischemic stroke.

Yet, the underlying regulatory mechanism of miRNAs in cerebral ischemic stroke remains unclear.

We investigated the role of miR-145 in cerebral ischemic stroke and its potential mechanism in a model using primary cultured astrocytes.

We detected the expression levels of miR-145 and its target gene AQP4 and assessed the role of miR-145 in cell death and apoptosis caused by oxygen-glucose deprivation (OGD).

Bioinformatics analysis was used to explore the targets of miR-145.

miR-145 expression levels were significantly decreased in primary astrocytes subjected to OGD.

miR-145 overexpression promoted astrocyte health and inhibited OGD-induced apoptosis.

AQP4 was a direct target of miR-145, and miR-145 suppressed AQP4 expression.

Moreover, AQP4 enhanced astrocyte injury in ischemic stroke, and AQP4 knockdown diminished the miR-145-mediated protective effect on ischemic injury.

Taken together, our results show that miR-145 plays an important role in protecting astrocytes from ischemic injury by downregulating AQP4 expression.

These findings may highlight a novel therapeutic target in cerebral ischemic stroke.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zheng, Lifang& Cheng, Wei& Wang, Xijia& Yang, Zhigang& Zhou, Xiangling& Pan, Chunlian. 2017. Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139584

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zheng, Lifang…[et al.]. Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139584

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zheng, Lifang& Cheng, Wei& Wang, Xijia& Yang, Zhigang& Zhou, Xiangling& Pan, Chunlian. Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139584

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1139584