LncRNA NONRATT021972 Was Associated with Neuropathic Pain Scoring in Patients with Type 2 Diabetes
المؤلفون المشاركون
Yu, Wei
Zhao, Guo-qing
Cao, Rang-juan
Zhu, Zhi-hua
Li, Kai
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Long noncoding RNAs were involved in the processes of diabetes.
Our study was aimed to explore clinical potential of LncRNA NONRATT021972 in diabetic neuropathic pain and investigate detailed mechanisms.
Methods.
154 patients with type 2 diabetes were enrolled as experimental group paired with control.
Patients without diabetes but neuropathy were enrolled to explore exclusive role of LncRNA NONRATT021972 in neuropathy.
Real-time PCR and ELISA were performed to examine expression of LncRNA and TNF-α in flood.
Neuropathic pain scores were calculated with data from NPQ.
Streptozotocin was used for SD adult male rats to establish diabetes for NONRATT021972 siRNA or saline treatment.
Neuropathic pain behaviors and expression of TNF-α were assessed.
Result.
Patients with type 2 diabetes had a significantly higher concentration of LncRNA NONRATT021972 in blood and more severe symptoms of neuropathic pain.
LncRNA NONRATT021972 was positively associated with neuropathic pain scores of type 2 diabetes.
TNF-α level increased in patients with type 2 diabetes.
Animal experiment showed that LncRNA NONRATT021972 siRNA attenuated inflammation via decreasing TNF-α and alleviated neuropathic pain.
Conclusion.
LncRNA NONRATT021972 increased in type 2 diabetes and was positively associated with neuropathic pain scoring in type 2 diabetes.
LncRNA NONRATT021972 exacerbated neuropathic pain via TNF-α related pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Wei& Zhao, Guo-qing& Cao, Rang-juan& Zhu, Zhi-hua& Li, Kai. 2017. LncRNA NONRATT021972 Was Associated with Neuropathic Pain Scoring in Patients with Type 2 Diabetes. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139762
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Wei…[et al.]. LncRNA NONRATT021972 Was Associated with Neuropathic Pain Scoring in Patients with Type 2 Diabetes. Behavioural Neurology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1139762
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Wei& Zhao, Guo-qing& Cao, Rang-juan& Zhu, Zhi-hua& Li, Kai. LncRNA NONRATT021972 Was Associated with Neuropathic Pain Scoring in Patients with Type 2 Diabetes. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139762
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139762
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر