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Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury
المؤلفون المشاركون
Soleimani Asl, Sara
Soleimani, M.
Mehdizadeh, Mehdi
Sakhaie, Mohammad Hassan
Pourheydar, Bagher
Atefimanesh, Pezhman
Madjd, Z.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Exposure to extremely low-frequency electromagnetic fields may induce constant modulation in neuronal plasticity.
In recent years, tremendous efforts have been made to design a suitable strategy for enhancing adult neurogenesis, which seems to be deterred due to brain senescence and several neurodegenerative diseases.
In this study, we evaluated the effects of ELF-EMF on neurogenesis and memory, following treatment with trimethyltin chloride (TMT) as a neurotoxicant.
The mice in all groups (n=56) were injected with BrdU during the experiment for seven consecutive days to label newborn cells.
Spatial memory was assessed by the Morris water maze (MWM) test.
By the end of the experiment, neurogenesis and neuronal differentiation were assessed in the hippocampus, using immunohistochemistry and Western blot analysis.
Based on the findings, exposure to ELF-EMF enhanced spatial learning and memory in the MWM test.
ELF-EMF exposure significantly enhanced the number of BrdU+ and NeuN+ cells in the dentate gyrus of adult mice (P<0.001 and P<0.05, resp.).
Western blot analysis revealed significant upregulation of NeuroD2 in ELF-EMF-exposed mice compared to the TMT-treated group (P<0.05).
These findings suggest that ELF-EMF might have clinical implications for the improvement of neurodegenerative processes and could help develop a novel therapeutic approach in regenerative medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sakhaie, Mohammad Hassan& Soleimani, M.& Pourheydar, Bagher& Madjd, Z.& Atefimanesh, Pezhman& Soleimani Asl, Sara…[et al.]. 2017. Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sakhaie, Mohammad Hassan…[et al.]. Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury. Behavioural Neurology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sakhaie, Mohammad Hassan& Soleimani, M.& Pourheydar, Bagher& Madjd, Z.& Atefimanesh, Pezhman& Soleimani Asl, Sara…[et al.]. Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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