Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis

الملخص EN

A 45-year-old obese man presented with persistent hematuria for 21 years.

At the age of 37, he developed hypertension and proteinuria which later increased up to 1.6 g/g creatinine.

Kidney biopsy revealed thin basement membrane nephropathy (TBMN) and focal segmental glomerulosclerosis (FSGS), which explained his urinary abnormalities.

Although a subgroup of TBMN can be complicated by FSGS, his FSGS was associated with obesity because of its histological features.

Reduction of body weight and increasing a dose of angiotensin-receptor blocker could transiently reduce the amount of proteinuria.

Clinicopathological implications of proteinuria after long-term hematuria by TBMN and FSGS were further discussed.