![](/images/graphics-bg.png)
Double Bolus Alteplase Therapy during Cardiopulmonary Resuscitation for Cardiac Arrest due to Massive Pulmonary Embolism Guided by Focused Bedside Echocardiography
المؤلفون المشاركون
Mahboob, Hafiz B.
Denney, Bruce W.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Massive pulmonary embolism (PE) frequently leads to cardiac arrest (CA) which carries an extremely high mortality rate.
Although available, randomized trials have not shown survival benefits from thrombolytic use.
Thrombolytics however have been used successfully during resuscitation in clinical practice in multiple case reports and in retrospective studies.
Recent resuscitation guidelines recommend using alteplase for PE related CA; however they do not offer a standardized treatment regimen.
The most consistently applied approach is an intravenous bolus of 50 mg tissue plasminogen activator (t-PA) early during cardiopulmonary resuscitation (CPR).
There is no consensus on the subsequent dosing.
We present a case in which two 50 mg boluses of t-PA were administered 20 minutes apart during CPR due to persistent hemodynamic compromise guided by bedside echocardiogram.
The patient had an excellent outcome with normalization of cardiac function and no neurologic sequela.
This case demonstrates the benefit of utilizing bedside echocardiography to guide administration of a second bolus of alteplase when there is persistent hemodynamic compromise despite achieving return of spontaneous circulation after the initial bolus, and there is evidence of persistent right ventricle dysfunction.
Future trials are warranted to help establish guidelines for thrombolytic use in cardiac arrest to maximize safety and efficacy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahboob, Hafiz B.& Denney, Bruce W.. 2018. Double Bolus Alteplase Therapy during Cardiopulmonary Resuscitation for Cardiac Arrest due to Massive Pulmonary Embolism Guided by Focused Bedside Echocardiography. Case Reports in Critical Care،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1141217
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahboob, Hafiz B.& Denney, Bruce W.. Double Bolus Alteplase Therapy during Cardiopulmonary Resuscitation for Cardiac Arrest due to Massive Pulmonary Embolism Guided by Focused Bedside Echocardiography. Case Reports in Critical Care No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1141217
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahboob, Hafiz B.& Denney, Bruce W.. Double Bolus Alteplase Therapy during Cardiopulmonary Resuscitation for Cardiac Arrest due to Massive Pulmonary Embolism Guided by Focused Bedside Echocardiography. Case Reports in Critical Care. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1141217
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141217
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)