![](/images/graphics-bg.png)
Dynamic Changes of the Frequency of Classic and Inflammatory Monocytes Subsets and Natural Killer Cells in Chronic Hepatitis C Patients Treated by Direct-Acting Antiviral Agents
المؤلفون المشاركون
Ning, Gang
Zeng, Yingfu
Chen, You-ming
Zhang, Ying
Li, Yi-ting
Lin, Chao-shuang
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Up to now, little was known about the immunological changes of chronic hepatitis C (CHC) patients treated with direct-acting antiviral agents (DAAs); we try to explore the effect of DAAs on the frequency of monocytes, NK cells, and cytokines that promote their activation.
Methods.
15 treatment-naive CHC patients and 10 healthy controls were recruited.
Patients were examined before DAAs therapy (0 w) and at week 4 (4 w) and week 12 (12 w) of therapy.
Percentage of monocytes and NK cells of the peripheral blood was analyzed by flow cytometry.
Serum cytokines IL-12, IL-18, CXCL10, CXCL11, sCD14, and sCD163 were measured by enzyme linked immunosorbent assay.
Results.
The frequency of CD3–CD16+CD56+ NK cells and classic CD14++CD16− monocytes decreased, while CD14+CD16+ monocytes and cytokines IL-12, IL-18, CXCL10, CXCL11, sCD14, and sCD163 increased at 0 w compared to healthy controls.
During DAAs treatment, the decreased NK cells and classic monocytes gradually increased to normal levels; the increased inflammatory monocytes and cytokines IL-12 and CXCL11 decreased to normal levels, but the increased cytokines IL-18, CXCL10, sCD14, and sCD163 still remained at high levels at 12 w though they decreased rapidly from 0 w.
Conclusion.
Our results showed that DAAs treatment attenuated the activation of monocytes and NK cells in CHC patients.
Trial registration number is NCT03063723.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ning, Gang& Li, Yi-ting& Chen, You-ming& Zhang, Ying& Zeng, Yingfu& Lin, Chao-shuang. 2017. Dynamic Changes of the Frequency of Classic and Inflammatory Monocytes Subsets and Natural Killer Cells in Chronic Hepatitis C Patients Treated by Direct-Acting Antiviral Agents. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141393
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ning, Gang…[et al.]. Dynamic Changes of the Frequency of Classic and Inflammatory Monocytes Subsets and Natural Killer Cells in Chronic Hepatitis C Patients Treated by Direct-Acting Antiviral Agents. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141393
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ning, Gang& Li, Yi-ting& Chen, You-ming& Zhang, Ying& Zeng, Yingfu& Lin, Chao-shuang. Dynamic Changes of the Frequency of Classic and Inflammatory Monocytes Subsets and Natural Killer Cells in Chronic Hepatitis C Patients Treated by Direct-Acting Antiviral Agents. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141393
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141393
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)