Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion
المؤلفون المشاركون
Costa, Elena
Pisani, Laura Francesca
Munizio, Nadia
Spina, Luisa
Cavallaro, Flaminia
Duca, Lorena
Rigolini, Roberta
Tontini, Gian Eugenio
Cappellini, Maria Domenica
Pastorelli, Luca
Vecchi, Maurizio
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and of anaemia of chronic disease (ACD).
ACD is characterized by macrophage iron retention induced by proinflammatory cytokines.
Hepcidin is the master inducer of iron accumulation during ACD, and its production is mainly regulated by IL-6 and the novel erythroid hormone erythroferrone (ERFE).
This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin production and the levels of its main regulators, leading to a restoration of iron homeostasis.
Methods.
Sera were collected from 21 IBD patients, before each anti-TNF administration, for the first 6 weeks of therapy.
Prohepcidin, erythropoietin, erythroferrone, C reactive protein, interleukin-6, iron markers, and haemoglobin levels were measured and clinical activity indexes were evaluated.
Results.
Serum prohepcidin, IL-6, CRP, and ferritin were significantly reduced after 6-week treatment; an increase in serum iron and total transferrin was observed.
No changes in the EPO-ERFE axis were found.
Remarkably, haemoglobin was significantly increased.
Conclusions.
Anti-TNF therapy improves iron metabolism and, subsequently, anaemia in IBD.
This effect appears to be related to the modulation of the cytokine network and specifically IL-6 leading to a relevant decrease of hepcidin, a master regulator of ACD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cavallaro, Flaminia& Duca, Lorena& Pisani, Laura Francesca& Rigolini, Roberta& Spina, Luisa& Tontini, Gian Eugenio…[et al.]. 2017. Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1141458
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cavallaro, Flaminia…[et al.]. Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1141458
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cavallaro, Flaminia& Duca, Lorena& Pisani, Laura Francesca& Rigolini, Roberta& Spina, Luisa& Tontini, Gian Eugenio…[et al.]. Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1141458
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141458
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر