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Cost-Effectiveness Analysis of Fosfomycin for Treatment of Uncomplicated Urinary Tract Infections in Ontario
المؤلفون المشاركون
Zhanel, George G.
Perrault, Louise
Dahan, Sybil
Iliza, Ange Christelle
LeLorier, Jacques
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background and Objective.
Bacterial resistance to antibiotics traditionally used to treat uncomplicated urinary tract infections (uUTIs) is rising in Canada.
We compared the cost-per-patient in Ontario of including fosfomycin (an antibiotic with a low resistance profile) as an option for first-line empirical treatment of uUTIs with current cost of treatment with sulfonamides, fluoroquinolones, and nitrofurantoin.
Methods.
A decision-tree model was used to perform a cost-minimization analysis.
All possible outcomes of a uUTI caused by bacterial species treated with either sulfonamides, fluoroquinolones, nitrofurantoin, or fosfomycin were included.
Results.
In the base case analysis, the cost-per-patient for treating uUTI with fosfomycin was $105.12.
This is similar to the cost-per-patient for each of the other currently reimbursed antibiotics (e.g., $96.19 for sulfonamides, $98.85 for fluoroquinolones, and $99.09 for nitrofurantoins).
The weighted average cost-per-patient for treating uUTI was not substantially elevated with the inclusion of fosfomycin in the treatment landscape ($98.41 versus $98.29 with and without fosfomycin, resp.).
The sensitivity analyses revealed that most (88.34%) of the potential variation in cost was associated with the probability of progressing to pyelonephritis and hospitalization for pyelonephritis.
Conclusion.
Fosfomycin in addition to being a safe and effective agent to treat uUTI has a low resistance profile, offers a single-dose treatment administration, and is similar in cost to other reimbursed antibiotics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Perrault, Louise& Dahan, Sybil& Iliza, Ange Christelle& LeLorier, Jacques& Zhanel, George G.. 2017. Cost-Effectiveness Analysis of Fosfomycin for Treatment of Uncomplicated Urinary Tract Infections in Ontario. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1141587
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Perrault, Louise…[et al.]. Cost-Effectiveness Analysis of Fosfomycin for Treatment of Uncomplicated Urinary Tract Infections in Ontario. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1141587
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Perrault, Louise& Dahan, Sybil& Iliza, Ange Christelle& LeLorier, Jacques& Zhanel, George G.. Cost-Effectiveness Analysis of Fosfomycin for Treatment of Uncomplicated Urinary Tract Infections in Ontario. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1141587
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141587
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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