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Radiolabeling and Quantitative In Vivo SPECTCT Imaging Study of Liposomes Using the Novel Iminothiolane-99mTc-Tricarbonyl Complex
المؤلفون المشاركون
Varga, Zoltán
Szigeti, Krisztián
Horváth, Ildikó
Máthé, Domokos
Szigyártó, Imola Cs.
Gyurkó, István
Dóczi, Rita
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The in vivo biodistribution of liposomal formulations greatly influences the pharmacokinetics of these novel drugs; therefore the radioisotope labeling of liposomes and the use of nuclear imaging methods for in vivo studies are of great interest.
In the present work, a new procedure for the surface labeling of liposomes is presented using the novel 99mTc-tricarbonyl complex.
Liposomes mimicking the composition of two FDA approved liposomal drugs were used.
In the first step of the labeling, thiol-groups were formed on the surface of the liposomes using Traut’s reagent, which were subsequently used to bind 99mTc-tricarbonyl complex to the liposomal surface.
The labeling efficiency determined by size exclusion chromatography was 95%, and the stability of the labeled liposomes in bovine serum was found to be 94% over 2 hours.
The obtained specific activity was 50 MBq per 1 μmol lipid which falls among the highest values reported for 99mTc labeling of liposomes.
Quantitative in vivo SPECT/CT biodistribution studies revealed distinct differences between the labeled liposomes and the free 99mTc-tricarbonyl, which indicates the in vivo stability of the labeling.
As the studied liposomes were non-PEGylated, fast clearance from the blood vessels and high uptake in the liver and spleen were observed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Varga, Zoltán& Szigyártó, Imola Cs.& Gyurkó, István& Dóczi, Rita& Horváth, Ildikó& Máthé, Domokos…[et al.]. 2017. Radiolabeling and Quantitative In Vivo SPECTCT Imaging Study of Liposomes Using the Novel Iminothiolane-99mTc-Tricarbonyl Complex. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Varga, Zoltán…[et al.]. Radiolabeling and Quantitative In Vivo SPECTCT Imaging Study of Liposomes Using the Novel Iminothiolane-99mTc-Tricarbonyl Complex. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Varga, Zoltán& Szigyártó, Imola Cs.& Gyurkó, István& Dóczi, Rita& Horváth, Ildikó& Máthé, Domokos…[et al.]. Radiolabeling and Quantitative In Vivo SPECTCT Imaging Study of Liposomes Using the Novel Iminothiolane-99mTc-Tricarbonyl Complex. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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