Gallium-68 Labeled Iron Oxide Nanoparticles Coated with 2,3-Dicarboxypropane-1,1-diphosphonic Acid as a Potential PETMR Imaging Agent: A Proof-of-Concept Study
المؤلفون المشاركون
Rouchota, Maritina
Karageorgou, Maria-Argyro
Vranješ-Djurić, Sanja
Radović, Magdalena
Lyberopoulou, Anna
Antić, Bratislav
Loudos, George
Xanthopoulos, Stavros
Sideratou, Zili
Stamopoulos, Dimosthenis
Bouziotis, Penelope
Tsoukalas, Charalampos
Gazouli, Maria
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The aim of this study was to develop a dual-modality PET/MR imaging probe by radiolabeling iron oxide magnetic nanoparticles (IONPs), surface functionalized with water soluble stabilizer 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD), with the positron emitter Gallium-68.
Magnetite nanoparticles (Fe3O4 MNPs) were synthesized via coprecipitation method and were stabilized with DPD.
The Fe3O4-DPD MNPs were characterized based on their structure, morphology, size, surface charge, and magnetic properties.
In vitro cytotoxicity studies showed reduced toxicity in normal cells, compared to cancer cells.
Fe3O4-DPD MNPs were successfully labeled with Gallium-68 at high radiochemical purity (>91%) and their stability in human serum and in PBS was demonstrated, along with their further characterization on size and magnetic properties.
The ex vivo biodistribution studies in normal Swiss mice showed high uptake in the liver followed by spleen.
The acquired PET images were in accordance with the ex vivo biodistribution results.
Our findings indicate that Ga68-Fe3O4-DPD MNPs could serve as an important diagnostic tool for biomedical imaging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karageorgou, Maria-Argyro& Vranješ-Djurić, Sanja& Radović, Magdalena& Lyberopoulou, Anna& Antić, Bratislav& Rouchota, Maritina…[et al.]. 2017. Gallium-68 Labeled Iron Oxide Nanoparticles Coated with 2,3-Dicarboxypropane-1,1-diphosphonic Acid as a Potential PETMR Imaging Agent: A Proof-of-Concept Study. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1141823
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karageorgou, Maria-Argyro…[et al.]. Gallium-68 Labeled Iron Oxide Nanoparticles Coated with 2,3-Dicarboxypropane-1,1-diphosphonic Acid as a Potential PETMR Imaging Agent: A Proof-of-Concept Study. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1141823
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karageorgou, Maria-Argyro& Vranješ-Djurić, Sanja& Radović, Magdalena& Lyberopoulou, Anna& Antić, Bratislav& Rouchota, Maritina…[et al.]. Gallium-68 Labeled Iron Oxide Nanoparticles Coated with 2,3-Dicarboxypropane-1,1-diphosphonic Acid as a Potential PETMR Imaging Agent: A Proof-of-Concept Study. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1141823
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141823
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر