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Invasive Aspergillosis in a Patient with Stage III (or 3a or 3b) Non-Small-Cell Lung Cancer Treated with Durvalumab
المؤلفون المشاركون
Guevara, Elizabeth
Gupta, Ashish
Tun, Aung
Ticona, Katy
Baqui, Aam
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-27
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Durvalumab is a therapeutic monoclonal antibody that blocks the checkpoint inhibitor, programmed death ligand 1 (PD-L1), resulting in T-cell activation and an antitumor response.
Durvalumab is approved for patients with unresectable stage III non-small-cell lung cancer (NSCLC) which has not progressed following platinum-based chemoradiotherapy.
A 63-year-old man presented to the emergency department with a 15-day history of increasing shortness of breath.
Several months previously, he had been diagnosed with a poorly differentiated stage IIIB NSCLC.
He had completed six cycles of chemotherapy with paclitaxel and carboplatin and four cycles of immunotherapy with durvalumab 13 days before his emergency hospital admission.
Computed tomography (CT) imaging showed a large left-sided loculated hydropneumothorax suggestive of empyema, patchy opacification of the left lung, and a left upper lobe lung mass.
Histology of the cell block from the pleural fluid and decorticated lung tissue showed hyphae suggestive of invasive Aspergillus fumigatus.
Treatment with voriconazole resulted in clinical improvement.
To our knowledge, this is the first reported case of pleural aspergillosis in a patient treated with durvalumab.
However, the increasing use of immune checkpoint inhibitors in oncology requires increased awareness by clinicians of immune-related adverse events (irAEs) due to opportunistic infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gupta, Ashish& Tun, Aung& Ticona, Katy& Baqui, Aam& Guevara, Elizabeth. 2019. Invasive Aspergillosis in a Patient with Stage III (or 3a or 3b) Non-Small-Cell Lung Cancer Treated with Durvalumab. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gupta, Ashish…[et al.]. Invasive Aspergillosis in a Patient with Stage III (or 3a or 3b) Non-Small-Cell Lung Cancer Treated with Durvalumab. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1141866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gupta, Ashish& Tun, Aung& Ticona, Katy& Baqui, Aam& Guevara, Elizabeth. Invasive Aspergillosis in a Patient with Stage III (or 3a or 3b) Non-Small-Cell Lung Cancer Treated with Durvalumab. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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