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Immune Checkpoint Inhibitor Induced Diabetes Mellitus Treated with Insulin and Metformin: Evolution of Diabetes Management in the Era of Immunotherapy
المؤلفون المشاركون
Saleem, Sameer
Alrifai, Taha
Ali, Faisal Shaukat
Ruiz, Diana Carolina Miranda
Rifai, Dana
Younas, Sundas
Qureshi, Faisal
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-04
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Immune checkpoint inhibitors (ICPIs) are a breakthrough therapy in oncology and have been approved by the Food and Drug Administration for the treatment of several malignancies.
ICPIs have been reported to cause immune-mediated damage of islet cells leading to ICPI-induced type 1 diabetes mellitus (T1DM).
These reports described patients presenting with severe diabetic ketoacidosis (DKA).
We present a case of a 69-year-old Caucasian male with type 2 diabetes suffering from non-small cell lung cancer and undergoing treatment with pembrolizumab, an anti-programmed cell death protein-1 antibody, who presented to our emergency department with complaints of nausea, vomiting, polyuria, and polydipsia.
He was found to have high anion gap metabolic acidosis with ketosis and elevated blood glucose levels consistent with DKA.
Lab workup was consistent with T1DM.
Despite being on a tailored insulin regimen, his blood glucose remained elevated, necessitating the addition of metformin to his regimen which effectively controlled his blood glucose.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alrifai, Taha& Ali, Faisal Shaukat& Saleem, Sameer& Ruiz, Diana Carolina Miranda& Rifai, Dana& Younas, Sundas…[et al.]. 2019. Immune Checkpoint Inhibitor Induced Diabetes Mellitus Treated with Insulin and Metformin: Evolution of Diabetes Management in the Era of Immunotherapy. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1142179
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alrifai, Taha…[et al.]. Immune Checkpoint Inhibitor Induced Diabetes Mellitus Treated with Insulin and Metformin: Evolution of Diabetes Management in the Era of Immunotherapy. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1142179
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alrifai, Taha& Ali, Faisal Shaukat& Saleem, Sameer& Ruiz, Diana Carolina Miranda& Rifai, Dana& Younas, Sundas…[et al.]. Immune Checkpoint Inhibitor Induced Diabetes Mellitus Treated with Insulin and Metformin: Evolution of Diabetes Management in the Era of Immunotherapy. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1142179
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142179
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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