Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide
المؤلفون المشاركون
Kapsali, Eleni
Gougopoulou, Dora
Bassukas, Ioannis D.
Gaitanis, Georgios
المصدر
Case Reports in Dermatological Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-27
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Hydroxycarbamide (HC) is the first-line treatment for certain myeloproliferative neoplasms, such as polycythemia vera and essential thrombocytosis (ET).
In a subset of these patients long-term treatment with HC can result in the development of confluent actinic keratoses (AK) followed by invasive keratinocytic carcinomas (“squamous dysplasia”), preferentially on sun-exposed skin.
Discontinuation or dose reduction of HC may result in partial improvement.
A 59-year-old farmer after 14 years on HC (2 gr/d) and acetylsalicylic acid (100 mg/d) for ET, was referred for numerous, hyperkeratotic AK on face, scalp, and hands that could not be controlled with repeated (N=15) cryosurgery sessions in the previous 3 years.
Acitretin (0.32 mg/kg daily) and topical treatments (cryosurgery with ingenol mebutate) were initiated with only marginal improvement after 3 months.
Acitretin dose was doubled and HC was switched to anagrelide (0.5 mg twice daily).
Within a month the AK load regressed significantly and, at 3 months follow-up, complete clinical remission was achieved and acitretin was discontinued.
Twenty months later the patient is clear from AK.
In conclusion, the impressive and sustainable AK remission under anagrelide draws attention to a possible role of the phosphodiesterase 3 pathway, the major pharmacological target of anagrelide, as a potential therapeutic target for keratinocytic cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gaitanis, Georgios& Gougopoulou, Dora& Kapsali, Eleni& Bassukas, Ioannis D.. 2018. Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide. Case Reports in Dermatological Medicine،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1142793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gaitanis, Georgios…[et al.]. Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide. Case Reports in Dermatological Medicine No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1142793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gaitanis, Georgios& Gougopoulou, Dora& Kapsali, Eleni& Bassukas, Ioannis D.. Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide. Case Reports in Dermatological Medicine. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1142793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر