A Case of Hyperacute Severe Thrombocytopenia Occurring Less than 24 Hours after Intravenous Tirofiban Infusion
المؤلفون المشاركون
Elsheshtawy, Moustafa
Sabharwal, N.
Meghrajani, Vineet
Namana, Vinod
Topi, Bernard
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Thrombocytopenia is defined as a condition where the platelet count is below the lower limit of normal (<150 G/L), and it is categorized as mild (100–149 G/L), moderate (50–99 G/L), and severe (<50 G/L).
We present here a 79-year-old man who developed severe thrombocytopenia with a platelet count of 6 G/L, less than 24 hours after intravenous tirofiban infusion that was given to the patient during a percutaneous transluminal coronary angioplasty procedure with placement of 3 drug-eluting stents.
The patient’s baseline platelet count was 233 G/L before the procedure.
Based on the timeline of events during hospitalization and laboratory evidence, it was highly likely that the patient’s thrombocytopenia was the result of tirofiban-induced immune thrombocytopenia, a type of drug-induced immune thrombocytopenia (DITP) which occurs due to drug-dependent antibody-mediated platelet destruction.
Anticoagulant-mediated artefactual pseudothrombocytopenia was ruled out as no platelet clumping was seen on the peripheral blood smears.
The treatment of DITP includes discontinuation of the causative drug; monitoring of platelet count recovery; or treatment of severe thrombocytopenia with glucocorticoids, IVIG, or platelet transfusions depending on the clinical presentation.
The most likely causative agent of this patient’s thrombocytopenia—tirofiban—was discontinued, and the patient did not develop any signs of bleeding during the remainder of his hospital stay.
His platelet count gradually improved to 24 G/L, and he was discharged on the sixth hospital day.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meghrajani, Vineet& Sabharwal, N.& Namana, Vinod& Elsheshtawy, Moustafa& Topi, Bernard. 2018. A Case of Hyperacute Severe Thrombocytopenia Occurring Less than 24 Hours after Intravenous Tirofiban Infusion. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1143847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meghrajani, Vineet…[et al.]. A Case of Hyperacute Severe Thrombocytopenia Occurring Less than 24 Hours after Intravenous Tirofiban Infusion. Case Reports in Hematology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1143847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meghrajani, Vineet& Sabharwal, N.& Namana, Vinod& Elsheshtawy, Moustafa& Topi, Bernard. A Case of Hyperacute Severe Thrombocytopenia Occurring Less than 24 Hours after Intravenous Tirofiban Infusion. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1143847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1143847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر